2-(2,6-Dichlorophenylamino)-1,7-dimethyl-6-(2-morpholin-4-yl-2-oxoethyl)-1,8-dihydro-imidazo[4,5-h]isoquinoline-9-one

Base Information

Chemical Name:2-(2,6-Dichlorophenylamino)-1,7-dimethyl-6-(2-morpholin-4-yl-2-oxoethyl)-1,8-dihydro-imidazo[4,5-h]isoquinoline-9-one
CAS No.:333455-20-2
Molecular Formula:C₂₄H₂₃Cl₂N₅O₃
Molecular Weight:500.384
Hs Code.:

Synonyms:2-(2,6-Dichlorophenylamino)-1,7-dimethyl-6-(2-morpholin-4-yl-2-oxoethyl)-1,8-dihydro-imidazo[4,5-h]isoquinoline-9-one

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Chemical Property of 2-(2,6-Dichlorophenylamino)-1,7-dimethyl-6-(2-morpholin-4-yl-2-oxoethyl)-1,8-dihydro-imidazo[4,5-h]isoquinoline-9-one

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Technology Process of 2-(2,6-Dichlorophenylamino)-1,7-dimethyl-6-(2-morpholin-4-yl-2-oxoethyl)-1,8-dihydro-imidazo[4,5-h]isoquinoline-9-one

There total 8 articles about 2-(2,6-Dichlorophenylamino)-1,7-dimethyl-6-(2-morpholin-4-yl-2-oxoethyl)-1,8-dihydro-imidazo[4,5-h]isoquinoline-9-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 110-91-8,99108-56-2
morpholine

: 333455-23-5
2-(2,6-Dichlorophenylamino)-1,7-dimethyl-9-oxo-1,8-dihydro-imidazo[4,5-h]isoquinolin-6-acetic acid ethyl ester

: 333455-20-2
2-(2,6-Dichlorophenylamino)-1,7-dimethyl-6-(2-morpholin-4-yl-2-oxoethyl)-1,8-dihydro-imidazo[4,5-h]isoquinoline-9-one

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm020446l

Reference yield:

: 5866-98-8
2,6-dichloro-3-nitrobenzonitrile

: 333455-20-2
2-(2,6-Dichlorophenylamino)-1,7-dimethyl-6-(2-morpholin-4-yl-2-oxoethyl)-1,8-dihydro-imidazo[4,5-h]isoquinoline-9-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: 83 percent / ethyl acetate; H₂O / 4.5 h / 10 - 20 °C

2.1: Cs₂CO₃ / dimethylformamide

3.1: H₂ / 10 percent Pd/C / methanol / 2585.74 Torr

4.1: tetrahydrofuran / 5 h / 20 °C

4.2: HgO / tetrahydrofuran

5.1: aq. H₂SO₄; AcOH / 2.5 h / 100 °C

6.1: H₂SO₄ / Heating

7.1: 84 percent / TBTU / dimethylformamide / 18 h / 20 °C

With sulfuric acid; hydrogen; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020446l

Reference yield:

: 333458-39-2
6-chloro-2-methylamino-3-nitrobenzonitrile

: 333455-20-2
2-(2,6-Dichlorophenylamino)-1,7-dimethyl-6-(2-morpholin-4-yl-2-oxoethyl)-1,8-dihydro-imidazo[4,5-h]isoquinoline-9-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: Cs₂CO₃ / dimethylformamide

2.1: H₂ / 10 percent Pd/C / methanol / 2585.74 Torr

3.1: tetrahydrofuran / 5 h / 20 °C

3.2: HgO / tetrahydrofuran

4.1: aq. H₂SO₄; AcOH / 2.5 h / 100 °C

5.1: H₂SO₄ / Heating

6.1: 84 percent / TBTU / dimethylformamide / 18 h / 20 °C

With sulfuric acid; hydrogen; caesium carbonate; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm020446l