Technology Process of 1H-Imidazo[4,5-h]isoquinoline-6-acetic acid,
2-[(2,6-dichlorophenyl)amino]-8,9-dihydro-1,7-dimethyl-9-oxo-, ethyl
ester
There total 6 articles about 1H-Imidazo[4,5-h]isoquinoline-6-acetic acid,
2-[(2,6-dichlorophenyl)amino]-8,9-dihydro-1,7-dimethyl-9-oxo-, ethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
2-acetyl-2-[4-cyano-2-(2,6-dichloro-phenylamino)-3-methyl-3H-benzoimidazol-5-yl]-succinic acid diethyl ester;
With
sulfuric acid;
In
water; acetic acid;
Heating;
ethanol;
With
sulfuric acid;
DOI:10.1016/S0040-4039(02)01802-6
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: 83 percent / ethyl acetate; H2O / 4.5 h / 10 - 20 °C
2.1: Cs2CO3 / dimethylformamide
3.1: H2 / 10 percent Pd/C / methanol / 2585.74 Torr
4.1: tetrahydrofuran / 5 h / 20 °C
4.2: HgO / tetrahydrofuran
5.1: aq. H2SO4; AcOH / 2.5 h / 100 °C
6.1: H2SO4 / Heating
With
sulfuric acid; hydrogen; caesium carbonate; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020446l
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: Cs2CO3 / dimethylformamide
2.1: H2 / 10 percent Pd/C / methanol / 2585.74 Torr
3.1: tetrahydrofuran / 5 h / 20 °C
3.2: HgO / tetrahydrofuran
4.1: aq. H2SO4; AcOH / 2.5 h / 100 °C
5.1: H2SO4 / Heating
With
sulfuric acid; hydrogen; caesium carbonate; acetic acid;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm020446l
