2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid

Base Information

Chemical Name:2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid
CAS No.:635322-20-2
Molecular Formula:C₃₆H₃₆O₉
Molecular Weight:612.676
Hs Code.:

Synonyms:2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid

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Chemical Property of 2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid

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Technology Process of 2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid

There total 4 articles about 2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 635322-19-9
2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid benzyl ester

: 635322-20-2
2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid

Guidance literature:: With ammonium acetate; hydrogen; palladium on activated charcoal; In methanol; at 20 ℃; for 1h;
DOI:10.1055/s-2003-40348

Reference yield:

: 100-39-0
benzyl bromide

: 635322-20-2
2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: Bu₂SnO / methanol / 1 h / Heating

1.2: 84 percent / dimethylformamide / 3 h / 90 °C

2.1: 83 percent / NaH / dimethylformamide / 1.5 h / 20 °C

3.1: 91 percent / H₂; NH₄OAc / Pd/C / methanol / 1 h / 20 °C

With ammonium acetate; hydrogen; sodium hydride; di(n-butyl)tin oxide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1055/s-2003-40348

Reference yield:

: 365535-43-9
2'-(benzyloxycarbonyl)benzyl 4,6-O-benzylidene-α-D-mannopyranoside

: 635322-20-2
2-[(2R,4aR,6S,7S,8S,8aR)-8-Benzyloxy-7-(4-methoxy-benzyloxy)-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxin-6-yloxymethyl]-benzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: Bu₂SnO / methanol / 1 h / Heating

1.2: 84 percent / dimethylformamide / 3 h / 90 °C

2.1: 83 percent / NaH / dimethylformamide / 1.5 h / 20 °C

3.1: 91 percent / H₂; NH₄OAc / Pd/C / methanol / 1 h / 20 °C

With ammonium acetate; hydrogen; sodium hydride; di(n-butyl)tin oxide; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide;
DOI:10.1055/s-2003-40348