{(3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidin-1-yl}-phenyl-methanone

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Chemical Name:{(3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidin-1-yl}-phenyl-methanone
CAS No.:708254-80-2
Molecular Formula:C₃₂H₃₉NO₂Si
Molecular Weight:497.753
Hs Code.:

Synonyms:{(3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidin-1-yl}-phenyl-methanone

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Chemical Property of {(3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidin-1-yl}-phenyl-methanone

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Technology Process of {(3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidin-1-yl}-phenyl-methanone

There total 6 articles about {(3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidin-1-yl}-phenyl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 98-88-4
benzoyl chloride

: 708254-79-9
(3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidine-1-carboxylic acid ethyl ester

: 708254-80-2
{(3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidin-1-yl}-phenyl-methanone

Guidance literature:: (3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidine-1-carboxylic acid ethyl ester; With methyllithium; at 0 ℃;

benzoyl chloride; Further stages.;
DOI:10.1016/j.tetlet.2004.03.085

Reference yield:

: (3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-(2-hydroxy-ethyl)-piperidine-1-carboxylic acid ethyl ester

: 708254-80-2
{(3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidin-1-yl}-phenyl-methanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: o-(NO₂)C₆H₄SeCN; PBu₃ / tetrahydrofuran

1.2: aq. H₂O₂ / tetrahydrofuran

2.1: 61 percent / MeLi / 0 °C

With ortho-nitrophenyl selenocyanate; tributylphosphine; methyllithium; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2004.03.085

Reference yield:

: 708254-78-8
(3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-[2-(2,2-dimethyl-propionyloxy)-ethyl]-piperidine-1-carboxylic acid ethyl ester

: 708254-80-2
{(3R,4S)-4-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-vinyl-piperidin-1-yl}-phenyl-methanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaOEt / ethanol / Heating

2.1: o-(NO₂)C₆H₄SeCN; PBu₃ / tetrahydrofuran

2.2: aq. H₂O₂ / tetrahydrofuran

3.1: 61 percent / MeLi / 0 °C

With ortho-nitrophenyl selenocyanate; tributylphosphine; methyllithium; sodium ethanolate; In tetrahydrofuran; ethanol;
DOI:10.1016/j.tetlet.2004.03.085