N-(2-(4-methoxyphenyl)diphenylmethylamino)ethyl-N-((N⁴-benzoyl-5-methylcytosin-1-yl)acetyl)glycine 2-cyanoethyl ester

Base Information

• Chemical Name: N-(2-(4-methoxyphenyl)diphenylmethylamino)ethyl-N-((N⁴-benzoyl-5-methylcytosin-1-yl)acetyl)glycine 2-cyanoethyl ester
• CAS No.: 272788-90-6
• Molecular Formula: C₄₁H₄₀N₆O₆
• Molecular Weight: 712.805

Synonyms:N-(2-(4-methoxyphenyl)diphenylmethylamino)ethyl-N-((N⁴-benzoyl-5-methylcytosin-1-yl)acetyl)glycine 2-cyanoethyl ester

Chemical Property of N-(2-(4-methoxyphenyl)diphenylmethylamino)ethyl-N-((N⁴-benzoyl-5-methylcytosin-1-yl)acetyl)glycine 2-cyanoethyl ester

Chemical Property:

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Technology Process of N-(2-(4-methoxyphenyl)diphenylmethylamino)ethyl-N-((N⁴-benzoyl-5-methylcytosin-1-yl)acetyl)glycine 2-cyanoethyl ester

There total 6 articles about N-(2-(4-methoxyphenyl)diphenylmethylamino)ethyl-N-((N⁴-benzoyl-5-methylcytosin-1-yl)acetyl)glycine 2-cyanoethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N4-benzoyl-1-carboxymethyl-5-methylcytosine (272788-89-3) + N-[2-(4-methoxyphenyl)diphenylmethylamino]ethyl-glycine 2-cyanoethyl ester → N-(2-(4-methoxyphenyl)diphenylmethylamino)ethyl-N-((N4-benzoyl-5-methylcytosin-1-yl)acetyl)glycine 2-cyanoethyl ester (272788-90-6)

Guidance literature:

With N-ethylmorpholine;; DIP; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; In N,N-dimethyl-formamide; at 20 ℃; for 20h;

DOI:10.1016/S0968-0896(99)00308-9

Reference yield:

benzoyl chloride (98-88-4) → N-(2-(4-methoxyphenyl)diphenylmethylamino)ethyl-N-((N4-benzoyl-5-methylcytosin-1-yl)acetyl)glycine 2-cyanoethyl ester (272788-90-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 65 percent / pyridine / 16 h / 20 °C

2: 72 percent / TFA / 0.67 h

3: 74 percent / N-ethylmorpholine; HOOBt; DIP / dimethylformamide / 20 h / 20 °C

With N-ethylmorpholine;; pyridine; DIP; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; trifluoroacetic acid; In N,N-dimethyl-formamide; 1: Acylation / 2: Hydrolysis / 3: Acylation;

DOI:10.1016/S0968-0896(99)00308-9

Reference yield:

N1-tert-butyloxycarbonylmethylthymine (272788-85-9) → N-(2-(4-methoxyphenyl)diphenylmethylamino)ethyl-N-((N4-benzoyl-5-methylcytosin-1-yl)acetyl)glycine 2-cyanoethyl ester (272788-90-6)

Guidance literature:

Multi-step reaction with 5 steps

1.1: 2-mesitylenecarbonyl chloride; Et₃N; DMAP / dimethylformamide / 3 h / 20 °C

1.2: 64 percent / 1,4-diazabicyclo[2.2.2]octane / 20 h

2.1: 68 percent / liquid NH₃ / tetrahydrofuran / 96 h / 75 °C

3.1: 65 percent / pyridine / 16 h / 20 °C

4.1: 72 percent / TFA / 0.67 h

5.1: 74 percent / N-ethylmorpholine; HOOBt; DIP / dimethylformamide / 20 h / 20 °C

With N-ethylmorpholine;; pyridine; dmap; DIP; ammonia; triethylamine; 3-hydroxy-3,4-dihydrobenzotriazine-4-one; trifluoroacetic acid; mesitylene-2-carboxylic acid chloride; In tetrahydrofuran; N,N-dimethyl-formamide; 1.1: Acylation / 1.2: Substitution / 2.1: Substitution / 3.1: Acylation / 4.1: Hydrolysis / 5.1: Acylation;

DOI:10.1016/S0968-0896(99)00308-9

upstream raw materials:

N⁴-benzoyl-1-carboxymethyl-5-methylcytosine

benzoyl chloride

1-(tert-butoxycarbonylmethyl)-5-methylcytosine

N₁-tert-butyloxycarbonylmethylthymine

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