methyl 3-<<<(benzoylamino)methylthio>methylene>amino>-4-<4-(benzyloxy)benzyl>-1H-pyrrole-2-carboxylate

Base Information

Chemical Name:methyl 3-<<<(benzoylamino)methylthio>methylene>amino>-4-<4-(benzyloxy)benzyl>-1H-pyrrole-2-carboxylate
CAS No.:146386-20-1
Molecular Formula:C₂₉H₂₇N₃O₄S
Molecular Weight:513.617
Hs Code.:

Synonyms:methyl 3-<<<(benzoylamino)methylthio>methylene>amino>-4-<4-(benzyloxy)benzyl>-1H-pyrrole-2-carboxylate

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Chemical Property of methyl 3-<<<(benzoylamino)methylthio>methylene>amino>-4-<4-(benzyloxy)benzyl>-1H-pyrrole-2-carboxylate

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Technology Process of methyl 3-<<<(benzoylamino)methylthio>methylene>amino>-4-<4-(benzyloxy)benzyl>-1H-pyrrole-2-carboxylate

There total 9 articles about methyl 3-<<<(benzoylamino)methylthio>methylene>amino>-4-<4-(benzyloxy)benzyl>-1H-pyrrole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 146386-06-3
methyl 3-<<(benzoylamino)thioxomethyl>amino>-4-<4-(benzyloxy)benzyl>-1H-pyrrole-2-carboxylate

: 74-88-4
methyl iodide

: 146386-20-1
methyl 3-<<<(benzoylamino)methylthio>methylene>amino>-4-<4-(benzyloxy)benzyl>-1H-pyrrole-2-carboxylate

Guidance literature:: With DBN; In dichloromethane; at 0 - 20 ℃; for 1.25h;
DOI:10.1021/jm00053a008

Reference yield:

: 4397-53-9
p-benzyloxybenzaldehyde

: 146386-20-1
methyl 3-<<<(benzoylamino)methylthio>methylene>amino>-4-<4-(benzyloxy)benzyl>-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: ammonium acetate, pyridine / pyridine; toluene / 44 h / Heating

2: Mg, MeOH

3: 17 percent / NaH / tetrahydrofuran / 1.) overnight, 2.) reflux, 30 min, 3.) RT, overnight

4: 85 percent / AcONa / methanol; H₂O / 48 h / Ambient temperature

5: 76 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 44 h

6: 82 percent / Na₂CO₃ / methanol / 24 h / Ambient temperature

7: 97 percent / CH₂Cl₂ / 1 h / Ambient temperature

8: 100 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 1.25 h / 0 - 20 °C

With pyridine; ammonium acetate; methanol; DBN; sodium acetate; sodium hydride; sodium carbonate; magnesium; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; toluene;
DOI:10.1021/jm00053a008

Reference yield:

: 705940-13-2
3-(4-benzyloxyphenyl)acrylonitrile

: 146386-20-1
methyl 3-<<<(benzoylamino)methylthio>methylene>amino>-4-<4-(benzyloxy)benzyl>-1H-pyrrole-2-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: Mg, MeOH

2: 17 percent / NaH / tetrahydrofuran / 1.) overnight, 2.) reflux, 30 min, 3.) RT, overnight

3: 85 percent / AcONa / methanol; H₂O / 48 h / Ambient temperature

4: 76 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 44 h

5: 82 percent / Na₂CO₃ / methanol / 24 h / Ambient temperature

6: 97 percent / CH₂Cl₂ / 1 h / Ambient temperature

7: 100 percent / 1,5-diazabicyclo<4.3.0>non-5-ene (DBN) / CH₂Cl₂ / 1.25 h / 0 - 20 °C

With methanol; DBN; sodium acetate; sodium hydride; sodium carbonate; magnesium; In tetrahydrofuran; methanol; dichloromethane; water;
DOI:10.1021/jm00053a008