2-[(2R,3R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-1,1,3,5-tetramethyl-2-triphenylsilanyloxy-oct-7-enyl]-[1,3]dithiane

Base Information

• Chemical Name: 2-[(2R,3R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-1,1,3,5-tetramethyl-2-triphenylsilanyloxy-oct-7-enyl]-[1,3]dithiane
• CAS No.: 186692-62-6
• Molecular Formula: C₄₀H₅₈O₂S₂Si₂
• Molecular Weight: 691.202

Synonyms:2-[(2R,3R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-1,1,3,5-tetramethyl-2-triphenylsilanyloxy-oct-7-enyl]-[1,3]dithiane

Chemical Property of 2-[(2R,3R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-1,1,3,5-tetramethyl-2-triphenylsilanyloxy-oct-7-enyl]-[1,3]dithiane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(2R,3R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-1,1,3,5-tetramethyl-2-triphenylsilanyloxy-oct-7-enyl]-[1,3]dithiane

There total 18 articles about 2-[(2R,3R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-1,1,3,5-tetramethyl-2-triphenylsilanyloxy-oct-7-enyl]-[1,3]dithiane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

Methylenetriphenylphosphorane (19493-09-5) + (3S,4S,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-[1,3]dithian-2-yl-3,5,7-trimethyl-6-triphenylsilanyloxy-octanal (186692-75-1) → 2-[(2R,3R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-1,1,3,5-tetramethyl-2-triphenylsilanyloxy-oct-7-enyl]-[1,3]dithiane (186692-62-6)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 1h;

DOI:10.1021/ja971946k

Reference yield: 76.0%

methyltriphenylphosphonium bromide + (3S,4S,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-[1,3]dithian-2-yl-3,5,7-trimethyl-6-triphenylsilanyloxy-octanal (186692-75-1) → 2-[(2R,3R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-1,1,3,5-tetramethyl-2-triphenylsilanyloxy-oct-7-enyl]-[1,3]dithiane (186692-62-6)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield: 76.0%

Methyltriphenylphosphonium bromide (1779-49-3) + (3S,4S,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-[1,3]dithian-2-yl-3,5,7-trimethyl-6-triphenylsilanyloxy-octanal (186692-75-1) → 2-[(2R,3R,4S,5S)-4-(tert-Butyl-dimethyl-silanyloxy)-1,1,3,5-tetramethyl-2-triphenylsilanyloxy-oct-7-enyl]-[1,3]dithiane (186692-62-6)

Guidance literature:

With sodium hexamethyldisilazane; In toluene;

upstream raw materials:

Methyltriphenylphosphonium bromide

(3S,4S,5R,6R)-4-(tert-Butyl-dimethyl-silanyloxy)-7-[1,3]dithian-2-yl-3,5,7-trimethyl-6-triphenylsilanyloxy-octanal

Methylenetriphenylphosphorane

t-butyldimethylsiyl triflate

Downstream raw materials:

epithilone A

epothilone B

desoxyepothilone A

Acetic acid (Z)-(1S,8S,9S,10R,11R)-9-(tert-butyl-dimethyl-silanyloxy)-8,10,12,12-tetramethyl-1-[(E)-1-methyl-2-(2-methyl-thiazol-4-yl)-vinyl]-13-oxo-11-triphenylsilanyloxy-tridec-3-enyl ester

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