N-(4-{4-(6-(2-methoxyethylamino)pyridin-3-yloxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Base Information

Chemical Name:N-(4-{4-(6-(2-methoxyethylamino)pyridin-3-yloxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide
CAS No.:1439936-59-0
Molecular Formula:C₂₅H₂₅N₅O₃S
Molecular Weight:475.571
Hs Code.:

Synonyms:N-(4-{4-(6-(2-methoxyethylamino)pyridin-3-yloxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

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Chemical Property of N-(4-{4-(6-(2-methoxyethylamino)pyridin-3-yloxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

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Technology Process of N-(4-{4-(6-(2-methoxyethylamino)pyridin-3-yloxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

There total 5 articles about N-(4-{4-(6-(2-methoxyethylamino)pyridin-3-yloxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

: 1005010-02-5
5-bromo-N-(2-methoxyethyl)pyridin-2-amine

: 1439935-97-3
N-(4-(4-hydroxy-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide

: 1439936-59-0
N-(4-{4-(6-(2-methoxyethylamino)pyridin-3-yloxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: N-(4-(4-hydroxy-2,6-dimethylphenyl)thiazol-2-yl)isonicotinamide; With copper; caesium carbonate; In N,N-dimethyl-formamide; at 100 - 110 ℃; for 1h;

5-bromo-N-(2-methoxyethyl)pyridin-2-amine; In N,N-dimethyl-formamide; at 140 ℃; for 48h;

Reference yield:

: 91060-92-3
1-(4-hydroxy-2,6-dimethylphenyl)ethanone

: 1439936-59-0
N-(4-{4-(6-(2-methoxyethylamino)pyridin-3-yloxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrabutylammomium bromide / acetonitrile / 1.5 h / 20 °C

2.1: ethanol / 2 h / Reflux

3.1: triethylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 1 h / 20 °C

4.1: caesium carbonate; copper / N,N-dimethyl-formamide / 1 h / 100 - 110 °C

4.2: 48 h / 140 °C

With tetrabutylammomium bromide; copper; benzotriazol-1-ol; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1072-97-5
5-bromo-2-pyridylamine

: 1439936-59-0
N-(4-{4-(6-(2-methoxyethylamino)pyridin-3-yloxy)-2,6-dimethylphenyl}thiazol-2-yl)isonicotinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0 - 5 °C / Inert atmosphere

1.2: 0.83 h / 0 °C

2.1: caesium carbonate; copper / N,N-dimethyl-formamide / 1 h / 100 - 110 °C

2.2: 48 h / 140 °C

With copper; sodium hydride; caesium carbonate; In N,N-dimethyl-formamide;