3-AMINO-2-BROMO-5-PICOLINE

Base Information

• Chemical Name: 3-AMINO-2-BROMO-5-PICOLINE
• CAS No.: 34552-14-2
• Molecular Formula: C6H7BrN2
• Molecular Weight: 187.04
• Hs Code.: 2933399090
• Mol file: 34552-14-2.mol

Synonyms:(2-Bromo-5-methylpyridin-3-yl)amine;3-Amino-2-bromo-5-methylpyridine;

Chemical Property of 3-AMINO-2-BROMO-5-PICOLINE

Chemical Property:

• Vapor Pressure: 0.000617mmHg at 25°C
• Melting Point: 103-106℃
• Refractive Index: 1.617
• Boiling Point: 310 °C at 760 mmHg
• PKA: 2.02±0.20(Predicted)
• Flash Point: 141.3 °C
• PSA: 38.91000
• Density: 1.593 g/cm³
• LogP: 2.31590
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C

Purity/Quality:

98%, ^*data from raw suppliers

2-Bromo-5-methylpyridin-3-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-AMINO-2-BROMO-5-PICOLINE

There total 3 articles about 3-AMINO-2-BROMO-5-PICOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-bromo-5-methyl-3-nitropyridine (23056-46-4) → 3-amino-2-bromo-5-methylpyridine (34552-14-2)

Guidance literature:

With iron; acetic acid; at 20 - 80 ℃; for 18.8333h;

Reference yield: 26.0%

5-methylpyridin-3-amine (3430-19-1) → 3-amino-2,6-dibromo-5-methylpyridine (126325-51-7) + 3-amino-2-bromo-5-methylpyridine (34552-14-2) + 3-amino-2,4,6-tribromo-5-methylpyridine

Guidance literature:

With hydrogen bromide; dihydrogen peroxide; at 70 ℃; for 1h; Product distribution;

Reference yield:

→ 3-amino-2-bromo-5-methylpyridine (34552-14-2)

Guidance literature:

2-Brom-3-nitro-5-methyl-pyridin, Fe/HOAc;

upstream raw materials:

5-methylpyridin-3-amine

2-bromo-5-methyl-3-nitropyridine

Refernces

• 1、 -. "HETEROARYL SULFONAMIDES AND CCR2". Page/Page column 205. . Retrieved 2008/06/13.