5-chloro-3-hydroxymethyl-6-methoxypyridine

Base Information

• Chemical Name: 5-chloro-3-hydroxymethyl-6-methoxypyridine
• CAS No.: 132865-53-3
• Molecular Formula: C7H8ClNO2
• Molecular Weight: 173.599
• Hs Code.: 2933399090
• Mol file: 132865-53-3.mol

Synonyms:(5-Chloro-6-methoxypyridin-3-yl)methanol;

Chemical Property of 5-chloro-3-hydroxymethyl-6-methoxypyridine

Chemical Property:

• Vapor Pressure: 0.002mmHg at 25°C
• Refractive Index: 1.553
• Boiling Point: 276.435 °C at 760 mmHg
• PKA: 13.06±0.10(Predicted)
• Flash Point: 120.984 °C
• PSA: 42.35000
• Density: 1.311 g/cm³
• LogP: 1.23590
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

(5-Chloro-6-methoxypyridin-3-yl)methanol >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-chloro-3-hydroxymethyl-6-methoxypyridine

There total 1 articles about 5-chloro-3-hydroxymethyl-6-methoxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5,6-dichloro-3-pyridinemethanol (54127-30-9) + sodium methylate (124-41-4) → (5-chloro-6-methoxy-pyridin-3-yl)-methanol (132865-53-3)

Guidance literature:

In methanol; Heating / reflux;

Reference yield: 72.0%

(5-chloro-6-methoxy-pyridin-3-yl)-methanol (132865-53-3) + 3-chloro-4-fluorobenzonitrile (117482-84-5) → 3-chloro-4-[(5-chloro-6-methoxypyridin-3-yl)methoxy]benzonitrile (1355489-12-1)

Guidance literature:

(5-chloro-6-methoxy-pyridin-3-yl)-methanol; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

3-chloro-4-fluorobenzonitrile; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 2h;

Reference yield:

(5-chloro-6-methoxy-pyridin-3-yl)-methanol (132865-53-3) → 3-chloro-4-[(5-chloro-6-methoxypyridin-3-yl)methoxy]-N-(methylsulfonyl)benzamide (1355488-36-6)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

1.2: 2 h / 20 °C

2.1: dihydrogen peroxide; potassium carbonate / dimethyl sulfoxide / 1 h / 20 °C

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.33 h

3.2: 18 h / 20 °C

With dihydrogen peroxide; sodium hydride; potassium carbonate; lithium hexamethyldisilazane; In tetrahydrofuran; dimethyl sulfoxide; N,N-dimethyl-formamide; mineral oil;

upstream raw materials:

5,6-dichloro-3-pyridinemethanol

sodium methylate

Downstream raw materials:

3-chloro-4-[(5-chloro-6-methoxypyridin-3-yl)methoxy]benzonitrile

3-chloro-4-[(5-chloro-6-methoxypyridin-3-yl)methoxy]-N-(methylsulfonyl)benzamide

3-chloro-4-[(5-chloro-6-methoxypyridin-3-yl)methoxy]benzamide

Refernces