sarcosine methyl ester

Base Information

• Chemical Name: sarcosine methyl ester
• CAS No.: 5473-12-1
• Molecular Formula: C4H9NO2
• Molecular Weight: 103.121
• Hs Code.: 2922499990
• Mol file: 5473-12-1.mol

Synonyms:Sarcosine,methyl ester (7CI,8CI);(Methylamino)acetic acid methyl ester;Methyl(methylamino)acetate;Methyl 2-(methylamino)acetate;Methyl N-methylglycinate;Methyl sarcosinate;Methyl[(methoxycarbonyl)methyl]amine;N-Methylglycine methyl ester;NSC 29650;

Chemical Property of sarcosine methyl ester

Chemical Property:

• Vapor Pressure: 16.3mmHg at 25°C
• Boiling Point: 118.9 °C at 760 mmHg
• PKA: 7.44±0.10(Predicted)
• Flash Point: 25.7 °C
• PSA: 38.33000
• Density: 0.964 g/cm³
• LogP: -0.23030
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

Purity/Quality:

99%, ^*data from raw suppliers

H-Sar-Ome 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl (Methylamino)acetate is used in preparation of Spiro compounds as an Acetyl-CoA Carboxylase inhibitor or treating diseases associated with ACC activity. Also, used in preparation of Nitroxoline derivatives for treatment of infection and cancer.

Technology Process of sarcosine methyl ester

There total 2 articles about sarcosine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methoxycarbonylmethylamine (616-34-2) → morpholine-2,5-dione (34037-21-3) + sarcosine (107-97-1,25951-24-0) + N-methylglycine methylester (5473-12-1) + dimethyl iminodiacetate (6096-81-7) + glycine (56-40-6,18875-39-3,25718-94-9)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; at 180 ℃; for 0.166667h; under 300.03 Torr;

DOI:10.1134/S0012500818110071

Reference yield:

glycine (56-40-6,18875-39-3,25718-94-9) → sarcosine (107-97-1,25951-24-0) + N-methylglycine methylester (5473-12-1) + glycylglycine (556-50-3) + iminodiacetic acid (142-73-4)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; at 180 ℃; for 0.166667h; under 300.03 Torr;

DOI:10.1134/S0012500818110071

Reference yield: 97.0%

N-methylglycine methylester (5473-12-1) + 2-fluoro-4-methoxy-1-nitro-benzene (446-38-8) → methyl 2-((5-methoxy-2-nitrophenyl)(methyl)amino)acetate

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 18h; Reflux;

DOI:10.1016/j.bmc.2018.07.042

upstream raw materials:

glycine

methoxycarbonylmethylamine

Downstream raw materials:

(+/-)-3-methyl-2t,5c-bis-(4-nitro-phenyl)-oxazolidine-4r-carboxylic acid methyl ester

(+/-)-3-methyl-2c,5t-bis-(4-nitro-phenyl)-oxazolidine-4r-carboxylic acid methyl ester

(+/-)-3-methyl-2t,5t-bis-(4-nitro-phenyl)-oxazolidine-4r-carboxylic acid methyl ester

[Methyl-(2-oxo-3-phenyl-propionyl)-amino]-acetic acid methyl ester

Refernces