2-chloro-5-fluoro-6-methylnicotinic acid methyl ester

Base Information

Chemical Name:2-chloro-5-fluoro-6-methylnicotinic acid methyl ester
CAS No.:1253383-90-2
Molecular Formula:C₈H₇ClFNO₂
Molecular Weight:203.6
Hs Code.:2933399990

Synonyms:2-chloro-5-fluoro-6-methylnicotinic acid methyl ester

Suppliers and Price of 2-chloro-5-fluoro-6-methylnicotinic acid methyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl2-Chloro-5-fluoro-6-methylnicotinate
5mg
$ 60.00

SynQuest Laboratories
Methyl 2-chloro-5-fluoro-6-methylnicotinate
250 mg
$ 437.00

Crysdot
Methyl2-Chloro-5-fluoro-6-methylnicotinate 95+%
5g
$ 832.00

Chemenu
Methyl2-Chloro-5-fluoro-6-methylnicotinate 95%
5g
$ 785.00

Apolloscientific
Methyl2-Chloro-5-fluoro-6-methylnicotinate
250mg
$ 273.00

Total 3 raw suppliers

Chemical Property of 2-chloro-5-fluoro-6-methylnicotinic acid methyl ester

Chemical Property:

Purity/Quality:

95+% ^*data from raw suppliers

Methyl2-Chloro-5-fluoro-6-methylnicotinate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-chloro-5-fluoro-6-methylnicotinic acid methyl ester

There total 1 articles about 2-chloro-5-fluoro-6-methylnicotinic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82671-06-5
2,6-dichloro-5-fluoro-3-pyridinecarboxylic acid

: 1253383-90-2
2-chloro-5-fluoro-6-methylnicotinic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: thionyl chloride; N,N-dimethyl-formamide / 5 h / 0 - 20 °C / Inert atmosphere

2: caesium carbonate / 110 °C / Inert atmosphere

With thionyl chloride; caesium carbonate; N,N-dimethyl-formamide;

Reference yield: 61.6%

: 1253383-90-2
2-chloro-5-fluoro-6-methylnicotinic acid methyl ester

: 1253383-91-3
5-fluoro-6-methylnicotinic acid methyl ester

Guidance literature:: With ammonium formate; palladium 10% on activated carbon; In methanol; at 20 ℃; for 1h; Inert atmosphere;

Reference yield:

: 1253383-90-2
2-chloro-5-fluoro-6-methylnicotinic acid methyl ester

: (S)-4-(5-chloro-3-(5-fluoro-6-methylnicotinamide)-2-methylphenyl)-2-methylpiperazine-1-carboxylic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: palladium on activated charcoal; sodium acetate; hydrogen / ethyl acetate / 20 °C / 760.05 Torr

2: sodium hydroxide; water / methanol; tetrahydrofuran / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 18 h / 20 °C

With palladium on activated charcoal; water; hydrogen; sodium acetate; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate;