N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)-4-methylbenzenesulfonamide
CAS No.:1217272-90-6
Molecular Formula:C₂₆H₂₄N₆O₅S
Molecular Weight:532.58
Hs Code.:

Synonyms:N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)-4-methylbenzenesulfonamide

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Chemical Property of N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)-4-methylbenzenesulfonamide

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Technology Process of N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)-4-methylbenzenesulfonamide

There total 3 articles about N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1217272-70-2
7-(4-methoxyphenyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione

: 1245644-89-6
N-(5-bromopyridin-3-yl)-4-methyl-N-tosylbenzenesulfonamide

: 1217272-90-6
N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)-4-methylbenzenesulfonamide

Guidance literature:: 7-(4-methoxyphenyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione; N-(5-bromopyridin-3-yl)-4-methyl-N-tosylbenzenesulfonamide; With copper(l) iodide; palladium diacetate; caesium carbonate; In N,N-dimethyl-formamide; at 130 - 140 ℃; for 40h; Inert atmosphere; Sealed tube;

With water; In dichloromethane; N,N-dimethyl-formamide; Inert atmosphere;
DOI:10.1021/ol100011n

Reference yield:

: 58-55-9,75448-53-2
theophylline

: 1217272-90-6
N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; copper diacetate / dichloromethane / 24 h / 40 °C / Inert atmosphere

2: copper(l) iodide; palladium diacetate; caesium carbonate / N,N-dimethyl-formamide / 40 h / 130 °C / Inert atmosphere

With pyridine; copper(l) iodide; copper diacetate; palladium diacetate; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.025

Reference yield:

: 5720-07-0
4-methoxyphenylboronic acid

: 1217272-90-6
N-(5-(7-(4-methoxyphenyl)-1,3-dimethyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl)pyridin-3-yl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine; copper diacetate / dichloromethane / 24 h / 40 °C / Inert atmosphere

2: copper(l) iodide; palladium diacetate; caesium carbonate / N,N-dimethyl-formamide / 40 h / 130 °C / Inert atmosphere

With pyridine; copper(l) iodide; copper diacetate; palladium diacetate; caesium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2011.03.025