(+/-)-benzyl 2-[(2,6-bis(benzyloxy)-4-{[(2-[N-(methoxymethylene)-N-(phenylsulfonyl)amino]-3-{4-[(methoxymethylene)oxy]phenyl}propyl)oxy]carbonyl}phenyl)carbonyl]-3-(benzyloxy)benzoate

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Chemical Name:(+/-)-benzyl 2-[(2,6-bis(benzyloxy)-4-{[(2-[N-(methoxymethylene)-N-(phenylsulfonyl)amino]-3-{4-[(methoxymethylene)oxy]phenyl}propyl)oxy]carbonyl}phenyl)carbonyl]-3-(benzyloxy)benzoate
CAS No.:184592-47-0
Molecular Formula:C₆₂H₅₇NO₁₃S
Molecular Weight:1056.2
Hs Code.:

(+/-)-benzyl 2-[(2,6-bis(benzyloxy)-4-{[(2-[N-(methoxymethylene)-N-(phenylsulfonyl)amino]-3-{4-[(methoxymethylene)oxy]phenyl}propyl)oxy]carbonyl}phenyl)carbonyl]-3-(benzyloxy)benzoate

Synonyms:(+/-)-benzyl 2-[(2,6-bis(benzyloxy)-4-{[(2-[N-(methoxymethylene)-N-(phenylsulfonyl)amino]-3-{4-[(methoxymethylene)oxy]phenyl}propyl)oxy]carbonyl}phenyl)carbonyl]-3-(benzyloxy)benzoate

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Chemical Property of (+/-)-benzyl 2-[(2,6-bis(benzyloxy)-4-{[(2-[N-(methoxymethylene)-N-(phenylsulfonyl)amino]-3-{4-[(methoxymethylene)oxy]phenyl}propyl)oxy]carbonyl}phenyl)carbonyl]-3-(benzyloxy)benzoate

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Technology Process of (+/-)-benzyl 2-[(2,6-bis(benzyloxy)-4-{[(2-[N-(methoxymethylene)-N-(phenylsulfonyl)amino]-3-{4-[(methoxymethylene)oxy]phenyl}propyl)oxy]carbonyl}phenyl)carbonyl]-3-(benzyloxy)benzoate

There total 7 articles about (+/-)-benzyl 2-[(2,6-bis(benzyloxy)-4-{[(2-[N-(methoxymethylene)-N-(phenylsulfonyl)amino]-3-{4-[(methoxymethylene)oxy]phenyl}propyl)oxy]carbonyl}phenyl)carbonyl]-3-(benzyloxy)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 184759-46-4
N-(phenylsulfonyl)-DL-tyrosine

: 184592-47-0
(+/-)-benzyl 2-[(2,6-bis(benzyloxy)-4-{[(2-[N-(methoxymethylene)-N-(phenylsulfonyl)amino]-3-{4-[(methoxymethylene)oxy]phenyl}propyl)oxy]carbonyl}phenyl)carbonyl]-3-(benzyloxy)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: 46 percent / N,N-diisopropylethylamine / acetonitrile / 1.5 h / 0 °C

2: 92 percent / LiBH₄ / tetrahydrofuran / 18 h

3: DBU / tetrahydrofuran / 72 h

With lithium borohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jm960581w

Reference yield:

: 3417-91-2,3728-20-9,68697-61-0
tyrosine methyl ester hydrochloride

: 184592-47-0
(+/-)-benzyl 2-[(2,6-bis(benzyloxy)-4-{[(2-[N-(methoxymethylene)-N-(phenylsulfonyl)amino]-3-{4-[(methoxymethylene)oxy]phenyl}propyl)oxy]carbonyl}phenyl)carbonyl]-3-(benzyloxy)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 40 percent / 1 N NaOH / CH₂Cl₂ / 2 h

2: 100 percent / aq. KOH / ethanol / 48 h / 60 °C

3: 46 percent / N,N-diisopropylethylamine / acetonitrile / 1.5 h / 0 °C

4: 92 percent / LiBH₄ / tetrahydrofuran / 18 h

5: DBU / tetrahydrofuran / 72 h

With potassium hydroxide; sodium hydroxide; lithium borohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm960581w

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 184592-47-0
(+/-)-benzyl 2-[(2,6-bis(benzyloxy)-4-{[(2-[N-(methoxymethylene)-N-(phenylsulfonyl)amino]-3-{4-[(methoxymethylene)oxy]phenyl}propyl)oxy]carbonyl}phenyl)carbonyl]-3-(benzyloxy)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1: 40 percent / 1 N NaOH / CH₂Cl₂ / 2 h

2: 100 percent / aq. KOH / ethanol / 48 h / 60 °C

3: 46 percent / N,N-diisopropylethylamine / acetonitrile / 1.5 h / 0 °C

4: 92 percent / LiBH₄ / tetrahydrofuran / 18 h

5: DBU / tetrahydrofuran / 72 h

With potassium hydroxide; sodium hydroxide; lithium borohydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethanol; dichloromethane; acetonitrile;
DOI:10.1021/jm960581w