3-[2-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-propanoic acid

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Chemical Name:3-[2-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-propanoic acid
CAS No.:1258975-55-1
Molecular Formula:C₂₀H₂₂ClN₅O₃S
Molecular Weight:447.945
Hs Code.:

Synonyms:3-[2-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-propanoic acid

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Chemical Property of 3-[2-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-propanoic acid

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Technology Process of 3-[2-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-propanoic acid

There total 7 articles about 3-[2-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: C₂₄H₃₀ClN₅O₃S

: 1258975-55-1
3-[2-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-propanoic acid

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1h;

Reference yield: 21.0%

: 1663-39-4,25232-27-3
tert-Butyl acrylate

: 1258975-51-7
2-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine trifluoroacetate

: 1258975-55-1
3-[2-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-propanoic acid

Guidance literature:: tert-Butyl acrylate; 2-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridine trifluoroacetate; With triethylamine; In tetrahydrofuran; butan-1-ol; at 100 ℃; for 2h; Microwave irradiation;

With trifluoroacetic acid; In tetrahydrofuran; butan-1-ol; at 20 ℃; for 1h;
DOI:10.1021/acs.jmedchem.5b01512

Reference yield:

: 1258440-64-0
2-bromo-5-(3-chloro-4-isopropoxyphenyl)-1,3,4-thiadiazole

: 1258975-55-1
3-[2-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,3,4-thiadiazol-2-yl)-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridin-5-yl]-propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; caesium carbonate / N,N-dimethyl-formamide / 1 h / 160 °C / Microwave irradiation

2.1: dichloromethane / 5 h / 20 °C

3.1: triethylamine / tetrahydrofuran; butan-1-ol / 2 h / 100 °C / Microwave irradiation

3.2: 1 h / 20 °C

With copper(l) iodide; caesium carbonate; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/acs.jmedchem.5b01512