5-butyl-2,4-dihydro-2-(2-oxo-2-phenylethyl)-4-<<2-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4'-yl>methyl>-3H-1,2,4-triazol-3-one

Base Information

• Chemical Name: 5-butyl-2,4-dihydro-2-(2-oxo-2-phenylethyl)-4-<<2-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4'-yl>methyl>-3H-1,2,4-triazol-3-one
• CAS No.: 149810-22-0
• Molecular Formula: C₄₇H₄₁N₇O₂
• Molecular Weight: 735.888

Synonyms:5-butyl-2,4-dihydro-2-(2-oxo-2-phenylethyl)-4-<<2-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4'-yl>methyl>-3H-1,2,4-triazol-3-one

Chemical Property of 5-butyl-2,4-dihydro-2-(2-oxo-2-phenylethyl)-4-<<2-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4'-yl>methyl>-3H-1,2,4-triazol-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-butyl-2,4-dihydro-2-(2-oxo-2-phenylethyl)-4-<<2-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4'-yl>methyl>-3H-1,2,4-triazol-3-one

There total 13 articles about 5-butyl-2,4-dihydro-2-(2-oxo-2-phenylethyl)-4-<<2-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4'-yl>methyl>-3H-1,2,4-triazol-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

α-bromoacetophenone (70-11-1) + 5-butyl-2,4-dihydro-4-<<2-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4'-yl>methyl>-3H-1,2,4-triazol-3-one (149810-21-9) → 5-butyl-2,4-dihydro-2-(2-oxo-2-phenylethyl)-4-<<2-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4'-yl>methyl>-3H-1,2,4-triazol-3-one (149810-22-0)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide; for 1h; Ambient temperature;

DOI:10.1021/jm00067a015

Reference yield:

2-Cyano-4'-methylbiphenyl (114772-53-1) → 5-butyl-2,4-dihydro-2-(2-oxo-2-phenylethyl)-4-<<2-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4'-yl>methyl>-3H-1,2,4-triazol-3-one (149810-22-0)

Guidance literature:

Multi-step reaction with 9 steps

1: NBS, AIBN / CCl₄ / Heating

2: NaN₃ / dimethylformamide / 24 h / Ambient temperature

3: H₂ / 10percent Pd/C / ethanol / 20 h / 2068.6 Torr

4: pyridine / toluene; CH₂Cl₂ / 1 h / 0 °C

5: pyridine / toluene; CH₂Cl₂ / 20 h / Ambient temperature

6: 93 percent / NaOCH₃ / methanol / 30 h / Heating

7: trimethyltin azide / dimethylformamide / 72 h / Heating

8: 94 percent / Et₃N / CHCl₃ / 48 h / Ambient temperature

9: 99 percent / t-BuOK / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature

With pyridine; N-Bromosuccinimide; sodium azide; 2,2'-azobis(isobutyronitrile); trimethyltin azide; potassium tert-butylate; hydrogen; sodium methylate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; tetrachloromethane; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00067a015

Reference yield:

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile (114772-54-2) → 5-butyl-2,4-dihydro-2-(2-oxo-2-phenylethyl)-4-<<2-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4'-yl>methyl>-3H-1,2,4-triazol-3-one (149810-22-0)

Guidance literature:

Multi-step reaction with 8 steps

1: NaN₃ / dimethylformamide / 24 h / Ambient temperature

2: H₂ / 10percent Pd/C / ethanol / 20 h / 2068.6 Torr

3: pyridine / toluene; CH₂Cl₂ / 1 h / 0 °C

4: pyridine / toluene; CH₂Cl₂ / 20 h / Ambient temperature

5: 93 percent / NaOCH₃ / methanol / 30 h / Heating

6: trimethyltin azide / dimethylformamide / 72 h / Heating

7: 94 percent / Et₃N / CHCl₃ / 48 h / Ambient temperature

8: 99 percent / t-BuOK / dimethylformamide; tetrahydrofuran / 1 h / Ambient temperature

With pyridine; sodium azide; trimethyltin azide; potassium tert-butylate; hydrogen; sodium methylate; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00067a015

upstream raw materials:

α-bromoacetophenone

5-butyl-2,4-dihydro-4-<<2-<1-(triphenylmethyl)-1H-tetrazol-5-yl><1,1'-biphenyl>-4'-yl>methyl>-3H-1,2,4-triazol-3-one

2-Cyano-4'-methylbiphenyl

4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

Downstream raw materials:

2-(1-Benzyl-2-oxo-2-phenyl-ethyl)-5-butyl-4-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-2,4-dihydro-[1,2,4]triazol-3-one

(2-{3-Butyl-5-oxo-4-[2'-(2-trityl-2H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-4,5-dihydro-[1,2,4]triazol-1-yl}-1-phenyl-ethoxy)-acetic acid ethyl ester

ethyl <2-<3-butyl-4,5-dihydro-5-oxo-4-<<2'-(1H-tetrazol-5-yl)<1,1'-biphenyl>-4-yl>methyl>-1H-1,2,4-triazol-1-yl>-1-phenylethoxy>acetate

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