ethyl (S)-4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:ethyl (S)-4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:854019-24-2
Molecular Formula:C₁₄H₁₅FN₂O₃
Molecular Weight:278.283
Hs Code.:

Synonyms:ethyl (S)-4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ethyl (S)-4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

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Technology Process of ethyl (S)-4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 4 articles about ethyl (S)-4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: C₁₅H₁₅FN₂O₃S

: 141-97-9
ethyl acetoacetate

: 854019-24-2
ethyl (S)-4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: C₁₅H₁₅FN₂O₃S; ethyl acetoacetate; With (S,S)-1,2-bis(2-hydroxybenzylamino)cyclohexane; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 15h;

With hydrogenchloride; In dichloromethane; water; at 20 ℃; for 5h; enantioselective reaction;
DOI:10.1002/chem.201604433

Reference yield: 85.0%

: 141-97-9
ethyl acetoacetate

: 459-57-4
4-fluorobenzaldehyde

: 57-13-6
urea

: 854019-24-2
ethyl (S)-4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: 4-fluorobenzaldehyde; urea; With 2,4,6-trichlorobenzoic acid; tert-gutylammonium 2,2,2-trifluoroacetate; In dichloromethane; at 25 ℃; for 1h;

ethyl acetoacetate; With N-[(1R,2R)-2-aminocyclohexyl]-N'-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)-thiourea; In dichloromethane; at 25 ℃; for 72h; optical yield given as %ee;
DOI:10.1002/adsc.200900597

Reference yield:

: 141-97-9
ethyl acetoacetate

: 459-57-4
4-fluorobenzaldehyde

: 57-13-6
urea

: 854019-24-2
ethyl (S)-4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

: 854019-23-1
ethyl (R)-4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With 9-epi-9-amino-9-deoxyquinine; hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 0 ℃; for 144h; optical yield given as %ee; enantioselective reaction;
DOI:10.1002/ejoc.201000448