Ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Base Information

Chemical Name:Ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
CAS No.:5937-24-6
Molecular Formula:C14H15FN2O3
Molecular Weight:278.283
Hs Code.:2933599090
European Community (EC) Number:621-802-2
DSSTox Substance ID:DTXSID70349493
Nikkaji Number:J973.630A
ChEMBL ID:CHEMBL1372560
Mol file:5937-24-6.mol

Synonyms:5937-24-6;ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate;Ethyl 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylate;ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-3,4-dihydro-1H-pyrimidine-5-carboxylate;ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-5-pyrimidinecarboxylate;SMR000008590;4-(4-Fluoro-phenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid ethyl ester;Oprea1_159475;Oprea1_214340;MLS000068877;MLS000103410;SCHEMBL5340383;CHEMBL1372560;DTXSID70349493;HMS2616H08;MFCD00500223;NSC772459;STK363922;AKOS000518102;AKOS016050364;JS-1496;NSC-772459;CS-0312976;EU-0044127;VU0096024-4;F71445;ETHYL4-(4-FLUOROPHENYL)-1234-TETRAH&;AG-690/11081046;SR-01000486612;SR-01000486612-1;Z47751395;F0126-0217;F1460-0010;Ethyl 4-(4-fluorophenyl)-6-methyl-2-(1H,3H)-pyrimidone-5-carboxylate;Ethyl 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylate, 97%

Suppliers and Price of Ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
Ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
250 mg
$ 144.00

SynQuest Laboratories
Ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
100 mg
$ 72.00

Sigma-Aldrich
Ethyl 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxylate 97%
5g
$ 72.40

Sigma-Aldrich
ETHYL 4-(4-FLUOROPHENYL)-6-METHYL-2-OXO-1,2,3,4-TETRAHYDRO-5-PYRIMIDINECARBOXYLATE Aldrich
1g
$ 32.30

Apolloscientific
Ethyl4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
100mg
$ 35.00

Apolloscientific
Ethyl4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate
250mg
$ 75.00

American Custom Chemicals Corporation
ETHYL 4-(4-FLUOROPHENYL)-1,2,3,4-TETRAHYDRO-6-METHYL-2-OXO-5-PYRIMIDINECARBOXYLATE 95.00%
1MG
$ 586.97

Total 8 raw suppliers

Chemical Property of Ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Chemical Property:

Melting Point:181-185 °C(lit.)
PSA：67.43000
LogP:2.67430
XLogP3:1.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:278.10667051
Heavy Atom Count:20
Complexity:428

Purity/Quality:

98% ^*data from raw suppliers

Ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:T
Statements: 25
Safety Statements: 45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CCOC(=O)C1=C(NC(=O)NC1C2=CC=C(C=C2)F)C

Technology Process of Ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

There total 10 articles about Ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 141-97-9
ethyl acetoacetate

: 459-57-4
4-fluorobenzaldehyde

: 57-13-6
urea

: 5937-24-6
ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With sulfonic acid immobilized on nano glass waste material; In neat (no solvent); at 100 ℃; for 0.25h;
DOI:10.1039/C6RA22791K

Reference yield: 99.0%

: 5937-24-6
ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: With toluene-4-sulfonic acid; In ethylene glycol; at 50 ℃; for 16h;

Reference yield: 93.0%

: 459-56-3
4-fluorobenzylic alcohol

: 141-97-9
ethyl acetoacetate

: 57-13-6
urea

: 5937-24-6
ethyl 4-(4-fluorophenyl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate

Guidance literature:: 4-fluorobenzylic alcohol; With bismuth(III) nitrate; In various solvent(s); at 50 ℃; for 0.0833333h;

ethyl acetoacetate; urea; In various solvent(s); at 90 ℃;
DOI:10.3987/COM-04-10257