5-chloro-4-[4-chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide trifluoroacetate

Base Information

Chemical Name:5-chloro-4-[4-chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide trifluoroacetate
CAS No.:1354818-76-0
Molecular Formula:C₂HF₃O₂*C₂₃H₁₉Cl₂FN₆O₃S₂
Molecular Weight:695.503
Hs Code.:

Synonyms:5-chloro-4-[4-chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide trifluoroacetate

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Chemical Property of 5-chloro-4-[4-chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide trifluoroacetate

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Technology Process of 5-chloro-4-[4-chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide trifluoroacetate

There total 3 articles about 5-chloro-4-[4-chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1235406-85-5
tert-butyl N-(5-chloro-2,4-difluoro-phenyl)sulfonyl-N-thiazol-4-yl-carbamate

: 1235407-36-9
tert-butyl 4-[4-(5-chloro-2-hydroxyphenyl)pyrimidin-2-yl]piperazine-1-carboxylate

: 76-05-1
trifluoroacetic acid

: 1354818-76-0
5-chloro-4-[4-chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide trifluoroacetate

Guidance literature:: tert-butyl N-(5-chloro-2,4-difluoro-phenyl)sulfonyl-N-thiazol-4-yl-carbamate; tert-butyl 4-[4-(5-chloro-2-hydroxyphenyl)pyrimidin-2-yl]piperazine-1-carboxylate; With potassium carbonate; In dimethyl sulfoxide; at 20 ℃; for 18h;

trifluoroacetic acid; In dichloromethane; for 2h;

Reference yield:

: 89488-25-5
(5‐chloro‐2‐hydroxyphenyl)boronic acid

: 1354818-76-0
5-chloro-4-[4-chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 4 h / 85 °C / Inert atmosphere

2.1: triethylamine / isopropyl alcohol / 18 h / 20 °C

3.1: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

3.2: 2 h

With sodium carbonate; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; dimethyl sulfoxide; isopropyl alcohol;

Reference yield:

: 1207535-01-0
2-chloro-4-(2-hydroxy-5-chlorophenyl)pyrimidine

: 1354818-76-0
5-chloro-4-[4-chloro-2-(2-piperazin-1-ylpyrimidin-4-yl)phenoxy]-2-fluoro-N-1,3-thiazol-4-ylbenzenesulfonamide trifluoroacetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / isopropyl alcohol / 18 h / 20 °C

2.1: potassium carbonate / dimethyl sulfoxide / 18 h / 20 °C

2.2: 2 h

With potassium carbonate; triethylamine; In dimethyl sulfoxide; isopropyl alcohol;