N-[3-Bromo-5-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-4-chloro-benzamide

Base Information

Chemical Name:N-[3-Bromo-5-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-4-chloro-benzamide
CAS No.:145028-62-2
Molecular Formula:C₁₈H₁₅BrClN₃OS
Molecular Weight:436.76
Hs Code.:

Synonyms:N-[3-Bromo-5-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-4-chloro-benzamide

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Chemical Property of N-[3-Bromo-5-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-4-chloro-benzamide

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Technology Process of N-[3-Bromo-5-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-4-chloro-benzamide

There total 5 articles about N-[3-Bromo-5-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-4-chloro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 122-01-0
4-chloro-benzoyl chloride

: 145235-67-2
6-(3-amino-5-bromophenyl)-2,3,5,6-tetrhydroimidazo<2,1-b>thiazole dihydrochloride

: 145028-62-2
N-[3-Bromo-5-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-4-chloro-benzamide

Guidance literature:: With sodium hydroxide; In methanol; water; Ambient temperature;
DOI:10.1016/0223-5234(92)90184-3

Reference yield:

: 6307-83-1
3-bromo-5-nitro-benzoic acid

: 145028-62-2
N-[3-Bromo-5-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-4-chloro-benzamide

Guidance literature:: Multi-step reaction with 8 steps

1: thionyl chloride / dimethylformamide / 3 h / Heating

2: 2.) 48percent HBr / 1.) CHCl₃, ether, from -50 deg C to RT, 2.) CH₂Cl₂, RT, 1 h

3: acetone / 1.) RT, 1 h, 2.) reflux, 0.5 h

4: NaBH₄ / methanol / 1 h / Ambient temperature

5: SOCl₂ / CHCl₃ / 1 h / Heating

6: aq. K₂CO₃ / CHCl₃ / 1 h / Heating

7: SnCl₂*2H₂O, conc. HCl / 1.) 40 deg C, 1 h, 2.) 70 deg C, 1.5 h

8: 50 percent / 2 M NaOH / methanol; H₂O / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium tetrahydroborate; thionyl chloride; hydrogen bromide; potassium carbonate; tin(ll) chloride; In methanol; chloroform; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/0223-5234(92)90184-3

Reference yield:

: 145028-77-9
1-(3-Bromo-5-nitro-phenyl)-2-(2-imino-thiazolidin-3-yl)-ethanol

: 145028-62-2
N-[3-Bromo-5-(2,3,5,6-tetrahydro-imidazo[2,1-b]thiazol-6-yl)-phenyl]-4-chloro-benzamide

Guidance literature:: Multi-step reaction with 4 steps

1: SOCl₂ / CHCl₃ / 1 h / Heating

2: aq. K₂CO₃ / CHCl₃ / 1 h / Heating

3: SnCl₂*2H₂O, conc. HCl / 1.) 40 deg C, 1 h, 2.) 70 deg C, 1.5 h

4: 50 percent / 2 M NaOH / methanol; H₂O / Ambient temperature

With hydrogenchloride; sodium hydroxide; thionyl chloride; potassium carbonate; tin(ll) chloride; In methanol; chloroform; water;
DOI:10.1016/0223-5234(92)90184-3