[5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde dimethyl acetal

Base Information

Chemical Name:[5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde dimethyl acetal
CAS No.:293329-60-9
Molecular Formula:C₂₂H₂₃N₃O₅
Molecular Weight:409.442
Hs Code.:

Synonyms:[5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde dimethyl acetal

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Chemical Property of [5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde dimethyl acetal

Chemical Property:

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MSDS Files:: SDS file from LookChem

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Technology Process of [5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde dimethyl acetal

There total 11 articles about [5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde dimethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 293329-57-4
1-(2,2-dimethoxyethyl)-6-oxo-2-phenyl-1,6-dihydropyrimidin-5-ylcarboxylic acid

: 100-51-6,185532-71-2
benzyl alcohol

: 293329-60-9
[5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde dimethyl acetal

Guidance literature:: 1-(2,2-dimethoxyethyl)-6-oxo-2-phenyl-1,6-dihydropyrimidin-5-ylcarboxylic acid; With diphenyl phosphoryl azide; triethylamine; In 1,4-dioxane; at 20 ℃; for 2h; Heating / reflux;

benzyl alcohol; In 1,4-dioxane; for 14h; Heating / reflux;

Reference yield:

: 501-53-1,94274-21-2
benzyl chloroformate

: 293329-59-6
5-amino-1-(2,2-dimethoxyethyl)-6-oxo-2-phenyl-1,6-dihydropyrimidine

: 293329-60-9
[5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde dimethyl acetal

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 ℃;
DOI:10.1055/s-2001-10786

Reference yield:

: 139721-85-0
α-chlorophenylformamidine hydrochloride

: 293329-60-9
[5-[(benzyloxycarbonyl)amino]-2-phenyl-6-oxo-1,6-dihydro-1-pyrimidinyl]acetaldehyde dimethyl acetal

Guidance literature:: Multi-step reaction with 4 steps

1: methanol / 72 h / 5 °C

2: methanol / 1.5 h / 100 °C

3: pyridine, lithium iodide / 2 h / Heating

4: 1.) Et₃N, diphenyl phosphorazidate / 1.) 100 deg C, 2 h, 2.) 100 deg C, 12 h

With pyridine; diphenyl phosphoryl azide; triethylamine; lithium iodide; In methanol;
DOI:10.1021/jm00001a015