tert-butyl {1-[4-(6-ethyl-8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)-phenyl]cyclobutyl}carbamate

Base Information

Chemical Name:tert-butyl {1-[4-(6-ethyl-8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)-phenyl]cyclobutyl}carbamate
CAS No.:1402609-08-8
Molecular Formula:C₃₀H₃₄N₄O₃
Molecular Weight:498.625
Hs Code.:

Synonyms:tert-butyl {1-[4-(6-ethyl-8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)-phenyl]cyclobutyl}carbamate

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Chemical Property of tert-butyl {1-[4-(6-ethyl-8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)-phenyl]cyclobutyl}carbamate

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Technology Process of tert-butyl {1-[4-(6-ethyl-8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)-phenyl]cyclobutyl}carbamate

There total 5 articles about tert-butyl {1-[4-(6-ethyl-8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)-phenyl]cyclobutyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1402609-05-5
tert-butyl {1-[4-(8-methoxy-3-phenyl-6-vinylimidazo[1,2-b]pyridazin-2-yl)-phenyl]cyclobutyl}carbamate

: 1402609-08-8
tert-butyl {1-[4-(6-ethyl-8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)-phenyl]cyclobutyl}carbamate

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol;

Reference yield:

: 1402608-89-2
tert-butyl (1-{4-[3-phenyl-6-bromo-8-methoxyimidazo[1,2-b]pyridazin-2-yl]-phenyl}cyclobutyl)carbamate

: 1402609-08-8
tert-butyl {1-[4-(6-ethyl-8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)-phenyl]cyclobutyl}carbamate

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / Inert atmosphere; Reflux

2: hydrogen / palladium on activated charcoal / methanol

With hydrogen; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In methanol; 1,2-dimethoxyethane; water;

Reference yield:

: 1032349-98-6
tert-butyl 1-(4-(2-phenylacetyl)phenyl)cyclobutylcarbamate

: 1402609-08-8
tert-butyl {1-[4-(6-ethyl-8-methoxy-3-phenylimidazo[1,2-b]pyridazin-2-yl)-phenyl]cyclobutyl}carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: pyridinium hydrobromide perbromide / tetrahydrofuran / 0.5 h / 0 °C

2: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 8 h / Reflux

3: methanol / 4 h / 20 °C / Cooling with ice

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 16 h / Inert atmosphere; Reflux

5: hydrogen / palladium on activated charcoal / methanol

With hydrogen; pyridinium hydrobromide perbromide; potassium carbonate; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; water; isopropyl alcohol;