N¹-(1H-1,2,3-benzotriazol-1-ylmethyl)-N²-(4-morpholin-4-ylbenzoyl)leucinamide

Base Information

Chemical Name:N¹-(1H-1,2,3-benzotriazol-1-ylmethyl)-N²-(4-morpholin-4-ylbenzoyl)leucinamide
CAS No.:870100-89-3
Molecular Formula:C₂₄H₃₀N₆O₃
Molecular Weight:450.541
Hs Code.:

N<sup>1</sup>-(1H-1,2,3-benzotriazol-1-ylmethyl)-N<sup>2</sup>-(4-morpholin-4-ylbenzoyl)leucinamide

Synonyms:N¹-(1H-1,2,3-benzotriazol-1-ylmethyl)-N²-(4-morpholin-4-ylbenzoyl)leucinamide

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Chemical Property of N¹-(1H-1,2,3-benzotriazol-1-ylmethyl)-N²-(4-morpholin-4-ylbenzoyl)leucinamide

Chemical Property:

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Technology Process of N¹-(1H-1,2,3-benzotriazol-1-ylmethyl)-N²-(4-morpholin-4-ylbenzoyl)leucinamide

There total 3 articles about N¹-(1H-1,2,3-benzotriazol-1-ylmethyl)-N²-(4-morpholin-4-ylbenzoyl)leucinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: N²-(4-morpholin-4-ylbenzoyl)leucinamide

: 95-14-7,27556-51-0
1,2,3-Benzotriazole

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 870100-89-3
N¹-(1H-1,2,3-benzotriazol-1-ylmethyl)-N²-(4-morpholin-4-ylbenzoyl)leucinamide

Guidance literature:: With toluene-4-sulfonic acid; In water; toluene; for 2h; Heating;
DOI:10.1021/jm0504961

Reference yield:

: 10466-61-2
(2S)-amino-4-methylpentanamide hydrochloride

: 870100-89-3
N¹-(1H-1,2,3-benzotriazol-1-ylmethyl)-N²-(4-morpholin-4-ylbenzoyl)leucinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / PyBOP; Et₃N / dimethylformamide / 20 °C

2: 37 percent / p-TsOH*H₂O / toluene; H₂O / 2 h / Heating

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; toluene-4-sulfonic acid; triethylamine; In water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0504961

Reference yield:

: 7470-38-4
4-morpholin-4-yl-benzoic acid

: 870100-89-3
N¹-(1H-1,2,3-benzotriazol-1-ylmethyl)-N²-(4-morpholin-4-ylbenzoyl)leucinamide

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / PyBOP; Et₃N / dimethylformamide / 20 °C

2: 37 percent / p-TsOH*H₂O / toluene; H₂O / 2 h / Heating

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; toluene-4-sulfonic acid; triethylamine; In water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm0504961