(R)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)thiophene-2-sulfonamide

Base Information

Chemical Name:(R)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)thiophene-2-sulfonamide
CAS No.:1589473-82-4
Molecular Formula:C₁₂H₁₀ClF₂NO₃S₂
Molecular Weight:353.798
Hs Code.:

Synonyms:(R)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)thiophene-2-sulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)thiophene-2-sulfonamide

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Technology Process of (R)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)thiophene-2-sulfonamide

There total 5 articles about (R)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)thiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 2766-74-7
5-chlorothien-2-ylsulfonyl chloride

: 957121-38-9
(R)-2-amino-2-(3,5-difluorophenyl)ethanol

: 1589473-82-4
(R)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)thiophene-2-sulfonamide

Guidance literature:: (R)-2-amino-2-(3,5-difluorophenyl)ethanol; With pyridine; In dichloromethane; at 20 ℃; for 0.25h;

5-chlorothien-2-ylsulfonyl chloride; In dichloromethane; for 24h;
DOI:10.1002/ardp.201300283

Reference yield:

: 105184-38-1
3,5-difluorophenyl acetic acid

: 1589473-82-4
(R)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: pivaloyl chloride; triethylamine / tetrahydrofuran / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 - 0 °C / Inert atmosphere

2.1: potassium hexamethylsilazane / tetrahydrofuran / 0.5 h / -78 °C / Inert atmosphere

2.2: 0.17 h / -78 °C / Inert atmosphere

3.1: lithium borohydride; water / tetrahydrofuran / 24.5 h / 0 - 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / Inert atmosphere

5.1: pyridine / dichloromethane / 0.25 h / 20 °C

5.2: 24 h

With pyridine; lithium borohydride; palladium 10% on activated carbon; water; hydrogen; pivaloyl chloride; potassium hexamethylsilazane; triethylamine; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/ardp.201300283

Reference yield:

: 1589473-79-9
(R)-3-((S)-2-azido-2-(3,5-difluorophenyl)acetyl)-4-benzyloxazolidin-2-one

: 1589473-82-4
(R)-5-chloro-N-(1-(3,5-difluorophenyl)-2-hydroxyethyl)thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium borohydride; water / tetrahydrofuran / 24.5 h / 0 - 20 °C

2.1: palladium 10% on activated carbon; hydrogen / methanol / 4 h / Inert atmosphere

3.1: pyridine / dichloromethane / 0.25 h / 20 °C

3.2: 24 h

With pyridine; lithium borohydride; palladium 10% on activated carbon; water; hydrogen; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1002/ardp.201300283