N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N-benzyl-N-isopropylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide

Base Information

• Chemical Name: N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N-benzyl-N-isopropylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide
• CAS No.: 847573-80-2
• Molecular Formula: C₃₁H₃₂IN₃O₅
• Molecular Weight: 653.517
• Mol file: 847573-80-2.mol

Synonyms:N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N-benzyl-N-isopropylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide

Chemical Property of N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N-benzyl-N-isopropylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N-benzyl-N-isopropylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide

There total 7 articles about N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N-benzyl-N-isopropylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(Benzylisopropylamino)acetonitril (50587-76-3) → N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N-benzyl-N-isopropylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide (847573-80-2)

Guidance literature:

Multi-step reaction with 3 steps

1.1: LiAlH₄ / tetrahydrofuran

2.1: phenol / 2.5 h / Heating

2.2: 68 percent / phenol / 20 h / Heating

3.1: 1.34 g / Et₃N / CH₂Cl₂ / 16 h / Heating

With lithium aluminium tetrahydride; triethylamine; phenol; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm049447z

Reference yield:

2-iodo-4,5-dimethoxybenzoic acid (61203-48-3) → N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N-benzyl-N-isopropylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide (847573-80-2)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride / CH₂Cl₂ / 4 h / Heating

2: 1.34 g / Et₃N / CH₂Cl₂ / 16 h / Heating

With oxalyl dichloride; triethylamine; In dichloromethane;

DOI:10.1021/jm049447z

Reference yield:

2-amino-4,5-methylenedioxy-acetophenone (28657-75-2) → N-(6,7-methylenedioxyquinolin-4-yl)-N-[2-(N-benzyl-N-isopropylamino)ethyl]-2-iodo-4,5-dimethoxybenzamide (847573-80-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 89 percent / NaH / Heating

2.1: 91 percent / POCl₃ / 2 h / Heating

3.1: phenol / 2.5 h / Heating

3.2: 68 percent / phenol / 20 h / Heating

4.1: 1.34 g / Et₃N / CH₂Cl₂ / 16 h / Heating

With sodium hydride; triethylamine; trichlorophosphate; phenol; In dichloromethane;

DOI:10.1021/jm049447z

upstream raw materials:

4,5-dimethoxy-2-iodobenzoyl chloride

4-[[2-(N-benzyl-N-isopropylamino)ethyl]amino]-6,7-methylenedioxyquinoline

(Benzylisopropylamino)acetonitril

2-iodo-4,5-dimethoxybenzoic acid

Downstream raw materials:

12-[2-(benzyl-isopropyl-amino)-ethyl]-2,3-dimethoxy-12H-8,10-dioxa-6,12-diaza-cyclopenta[b]chrysen-13-one