5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

Base Information

Chemical Name:5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline
CAS No.:1192829-34-7
Molecular Formula:C₂₀H₁₆ClN₃O₂
Molecular Weight:365.819
Hs Code.:

Synonyms:5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

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Chemical Property of 5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

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Technology Process of 5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

There total 6 articles about 5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1192829-62-1
N-hydroxy-5-isoquinolinecarboximidamide

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1192829-34-7
5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

Guidance literature:: With triethylamine; HATU; at 20 - 130 ℃; for 2.5h; Microwave irradiation;

Reference yield:

: 1192829-62-1
N-hydroxy-5-isoquinolinecarboximidamide

: 213767-19-2
3-chloro-4-[(1-methylethyl)oxy]benzoyl chloride

: 1192829-34-7
5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 - 120 ℃; Product distribution / selectivity; Inert atmosphere;

Reference yield:

: 3964-57-6
methyl 4-hydroxy-3-chlorobenzoate

: 1192829-34-7
5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: water; sodium hydroxide / methanol / 20 °C

2.2: pH 1 - 2 / Acidification

3.1: triethylamine; HATU / 2.5 h / 20 - 130 °C / Microwave irradiation

With water; potassium carbonate; triethylamine; HATU; sodium hydroxide; In methanol; N,N-dimethyl-formamide;