1-chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

Base Information

Chemical Name:1-chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline
CAS No.:1192829-65-4
Molecular Formula:C₂₀H₁₅Cl₂N₃O₂
Molecular Weight:400.264
Hs Code.:

Synonyms:1-chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

Suppliers and Price of 1-chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

There total 7 articles about 1-chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1192829-64-3
5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline 2-oxide

: 1192829-65-4
1-chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

Guidance literature:: 5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline 2-oxide; With trichlorophosphate; at 20 - 65 ℃; for 4.25h; Inert atmosphere;

With sodium hydroxide; In dichloromethane; water;

Reference yield:

: 3964-57-6
methyl 4-hydroxy-3-chlorobenzoate

: 1192829-65-4
1-chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 18 h / 20 °C

2.1: water; sodium hydroxide / methanol / 20 °C

2.2: pH 1 - 2 / Acidification

3.1: triethylamine; HATU / 2.5 h / 20 - 130 °C / Microwave irradiation

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

5.1: trichlorophosphate / 4.25 h / 20 - 65 °C / Inert atmosphere

With water; potassium carbonate; triethylamine; 3-chloro-benzenecarboperoxoic acid; HATU; sodium hydroxide; trichlorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 213598-07-3
3-chloro-4-isopropoxy-benzoic acid

: 1192829-65-4
1-chloro-5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)isoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; HATU / 2.5 h / 20 - 130 °C / Microwave irradiation

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1.5 h / 20 °C

3: trichlorophosphate / 4.25 h / 20 - 65 °C / Inert atmosphere

With triethylamine; 3-chloro-benzenecarboperoxoic acid; HATU; trichlorophosphate; In dichloromethane;