[1-(2-Dimethoxymethyl-phenyl)-meth-(E)-ylidene]-prop-2-ynyl-amine

Base Information

• Chemical Name: [1-(2-Dimethoxymethyl-phenyl)-meth-(E)-ylidene]-prop-2-ynyl-amine
• CAS No.: 445425-72-9
• Molecular Formula: C₁₃H₁₅NO₂
• Molecular Weight: 217.268
• Mol file: 445425-72-9.mol

Synonyms:[1-(2-Dimethoxymethyl-phenyl)-meth-(E)-ylidene]-prop-2-ynyl-amine

Chemical Property of [1-(2-Dimethoxymethyl-phenyl)-meth-(E)-ylidene]-prop-2-ynyl-amine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [1-(2-Dimethoxymethyl-phenyl)-meth-(E)-ylidene]-prop-2-ynyl-amine

There total 3 articles about [1-(2-Dimethoxymethyl-phenyl)-meth-(E)-ylidene]-prop-2-ynyl-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(dimethoxymethyl)benzaldehyde (132233-84-2) + Propargylamine (2450-71-7) → [1-(2-Dimethoxymethyl-phenyl)-meth-(E)-ylidene]-prop-2-ynyl-amine (445425-72-9)

Guidance literature:

With magnesium sulfate; In dichloromethane;

DOI:10.1039/b102046n

Reference yield:

o-bromobenzaldehyde dimethyl acetal (35849-09-3) → [1-(2-Dimethoxymethyl-phenyl)-meth-(E)-ylidene]-prop-2-ynyl-amine (445425-72-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

1.2: 98 percent / tetrahydrofuran / -78 - 20 °C

2.1: 100 percent / MgSO₄ / CH₂Cl₂

With n-butyllithium; magnesium sulfate; In tetrahydrofuran; dichloromethane;

DOI:10.1039/b102046n

Reference yield:

ortho-bromobenzaldehyde (6630-33-7) → [1-(2-Dimethoxymethyl-phenyl)-meth-(E)-ylidene]-prop-2-ynyl-amine (445425-72-9)

Guidance literature:

Multi-step reaction with 3 steps

1.1: 92 percent / Dowex 5OWX₈-200 / methanol / 18 h / Heating

2.1: n-BuLi / tetrahydrofuran / 0.5 h / -78 °C

2.2: 98 percent / tetrahydrofuran / -78 - 20 °C

3.1: 100 percent / MgSO₄ / CH₂Cl₂

With n-butyllithium; Dowex 5OWX₈-200; magnesium sulfate; In tetrahydrofuran; methanol; dichloromethane;

DOI:10.1039/b102046n

upstream raw materials:

2-(dimethoxymethyl)benzaldehyde

Propargylamine

o-bromobenzaldehyde dimethyl acetal

ortho-bromobenzaldehyde

Downstream raw materials:

(2-dimethoxymethyl-benzyl)-prop-2-ynyl-amine

N-(2-formyl-benzyl)-2-iodo-N-prop-2-ynyl-benzamide

N-(2-hydroxymethyl-benzyl)-2-iodo-N-propa-1,2-dienyl-benzamide

N-(2-hydroxymethyl-benzyl)-2-iodo-N-prop-2-ynyl-benzamide