7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester

Base Information

Chemical Name:7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester
CAS No.:1455091-65-2
Molecular Formula:C₁₈H₁₃F₂NO₄
Molecular Weight:345.302
Hs Code.:

Synonyms:7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester

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Chemical Property of 7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester

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Technology Process of 7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester

There total 3 articles about 7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1455091-64-1
4-(2,6-difluorophenoxy)-2-{[(2,4-dimethoxybenzyl)(ethoxycarbonylmethyl)amino]methyl}benzoic acid ethyl ester

: 1455091-65-2
7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester

Guidance literature:: 4-(2,6-difluorophenoxy)-2-{[(2,4-dimethoxybenzyl)(ethoxycarbonylmethyl)amino]methyl}benzoic acid ethyl ester; With potassium 2-methylbutan-2-olate; In tetrahydrofuran; toluene; at 20 ℃; for 0.5h; Cooling with ice;

With thionyl chloride; In dichloromethane;

Reference yield:

: 260561-85-1
4-bromo-2-(bromomethyl)benzoic acid ethyl ester

: 1455091-65-2
7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine; sodium iodide / N,N-dimethyl-formamide / 20 °C

2: copper(l) chloride; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate / 1-methyl-pyrrolidin-2-one / 24 h / 130 °C

3: potassium 2-methylbutan-2-olate / tetrahydrofuran; toluene / 0.5 h / 20 °C / Cooling with ice

With 2,2,6,6-tetramethylheptane-3,5-dione; potassium 2-methylbutan-2-olate; caesium carbonate; N-ethyl-N,N-diisopropylamine; sodium iodide; copper(l) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1455091-61-8
4-bromo-2-{[(2,4-dimethoxybenzyl)(ethoxycarbonylmethyl)amino]methyl}benzoic acid ethyl ester

: 1455091-65-2
7-(2,6-difluorophenoxy)-4-hydroxyisoquinoline-3-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) chloride; 2,2,6,6-tetramethylheptane-3,5-dione; caesium carbonate / 1-methyl-pyrrolidin-2-one / 24 h / 130 °C

2: potassium 2-methylbutan-2-olate / tetrahydrofuran; toluene / 0.5 h / 20 °C / Cooling with ice

With 2,2,6,6-tetramethylheptane-3,5-dione; potassium 2-methylbutan-2-olate; caesium carbonate; copper(l) chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; toluene;