(-)-1-(((1R,2S,3R)-2-(tert-butyldimethylsilyloxy)-3-((tert-butyldiphenylsilyloxy)methyl)-3-(4,4-dimethylhepta-1,6-dien-2-yl)cyclobutyloxy)methyl)-4-methoxybenzene

Base Information

• Chemical Name: (-)-1-(((1R,2S,3R)-2-(tert-butyldimethylsilyloxy)-3-((tert-butyldiphenylsilyloxy)methyl)-3-(4,4-dimethylhepta-1,6-dien-2-yl)cyclobutyloxy)methyl)-4-methoxybenzene
• CAS No.: 960294-56-8
• Molecular Formula: C₄₄H₆₄O₄Si₂
• Molecular Weight: 713.161
• Mol file: 960294-56-8.mol

Synonyms:(-)-1-(((1R,2S,3R)-2-(tert-butyldimethylsilyloxy)-3-((tert-butyldiphenylsilyloxy)methyl)-3-(4,4-dimethylhepta-1,6-dien-2-yl)cyclobutyloxy)methyl)-4-methoxybenzene

Chemical Property of (-)-1-(((1R,2S,3R)-2-(tert-butyldimethylsilyloxy)-3-((tert-butyldiphenylsilyloxy)methyl)-3-(4,4-dimethylhepta-1,6-dien-2-yl)cyclobutyloxy)methyl)-4-methoxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (-)-1-(((1R,2S,3R)-2-(tert-butyldimethylsilyloxy)-3-((tert-butyldiphenylsilyloxy)methyl)-3-(4,4-dimethylhepta-1,6-dien-2-yl)cyclobutyloxy)methyl)-4-methoxybenzene

There total 1 articles about (-)-1-(((1R,2S,3R)-2-(tert-butyldimethylsilyloxy)-3-((tert-butyldiphenylsilyloxy)methyl)-3-(4,4-dimethylhepta-1,6-dien-2-yl)cyclobutyloxy)methyl)-4-methoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(-)-1-((1R,2S,3R)-3-(4-methoxybenzyloxy)-2-(tert-butyldimethylsilyloxy)-1-((tert-butyldiphenylsilyloxy)methyl)cyclobutyl)-3,3-dimethylhex-5-en-1-one (960294-55-7) + trimethylsilylmethyllithium (1822-00-0) → (-)-1-(((1R,2S,3R)-2-(tert-butyldimethylsilyloxy)-3-((tert-butyldiphenylsilyloxy)methyl)-3-(4,4-dimethylhepta-1,6-dien-2-yl)cyclobutyloxy)methyl)-4-methoxybenzene (960294-56-8)

Guidance literature:

(-)-1-((1R,2S,3R)-3-(4-methoxybenzyloxy)-2-(tert-butyldimethylsilyloxy)-1-((tert-butyldiphenylsilyloxy)methyl)cyclobutyl)-3,3-dimethylhex-5-en-1-one; trimethylsilylmethyllithium; In toluene; pentane; at -78 ℃; for 2h;

With toluene-4-sulfonic acid; In benzene; at 20 ℃; for 5h; Further stages.;

DOI:10.1002/anie.200702056

Reference yield: 91.0%

(-)-1-(((1R,2S,3R)-2-(tert-butyldimethylsilyloxy)-3-((tert-butyldiphenylsilyloxy)methyl)-3-(4,4-dimethylhepta-1,6-dien-2-yl)cyclobutyloxy)methyl)-4-methoxybenzene (960294-56-8) → C42H60O4Si2 (960294-70-6)

Guidance literature:

tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In benzene; for 6h; Heating;

DOI:10.1002/anie.200702056 DOI:10.1021/jo8004233

upstream raw materials:

(-)-1-((1R,2S,3R)-3-(4-methoxybenzyloxy)-2-(tert-butyldimethylsilyloxy)-1-((tert-butyldiphenylsilyloxy)methyl)cyclobutyl)-3,3-dimethylhex-5-en-1-one

trimethylsilylmethyllithium

Downstream raw materials:

C₄₂H₆₀O₄Si₂