(3S)-(-)-1-di(p-anisyl)methyl-7-chloro-1,3-dihydro-5-phenyl-3-(2-thiomethyl)ethyl-2H-1,4-benzodiazepin-2-one

Base Information

Chemical Name:(3S)-(-)-1-di(p-anisyl)methyl-7-chloro-1,3-dihydro-5-phenyl-3-(2-thiomethyl)ethyl-2H-1,4-benzodiazepin-2-one
CAS No.:918159-87-2
Molecular Formula:C₃₃H₃₁ClN₂O₃S
Molecular Weight:571.14
Hs Code.:

Synonyms:(3S)-(-)-1-di(p-anisyl)methyl-7-chloro-1,3-dihydro-5-phenyl-3-(2-thiomethyl)ethyl-2H-1,4-benzodiazepin-2-one

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Chemical Property of (3S)-(-)-1-di(p-anisyl)methyl-7-chloro-1,3-dihydro-5-phenyl-3-(2-thiomethyl)ethyl-2H-1,4-benzodiazepin-2-one

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Technology Process of (3S)-(-)-1-di(p-anisyl)methyl-7-chloro-1,3-dihydro-5-phenyl-3-(2-thiomethyl)ethyl-2H-1,4-benzodiazepin-2-one

There total 2 articles about (3S)-(-)-1-di(p-anisyl)methyl-7-chloro-1,3-dihydro-5-phenyl-3-(2-thiomethyl)ethyl-2H-1,4-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 7-chloro-3-(2-methylsulfanyl-ethyl)-5-phenyl-1,3-dihydro-benzo[e][1,4]diazepin-2-one

: 69545-37-5
di(p-anisyl)methyl bromide

: 918159-87-2
(3S)-(-)-1-di(p-anisyl)methyl-7-chloro-1,3-dihydro-5-phenyl-3-(2-thiomethyl)ethyl-2H-1,4-benzodiazepin-2-one

Guidance literature:: With sodium hydride; In tetrahydrofuran; at 0 ℃; for 4h;
DOI:10.1021/ja0640142

Reference yield:

: 728-87-0
4,4'-Dimethoxybenzhydrol

: 918159-87-2
(3S)-(-)-1-di(p-anisyl)methyl-7-chloro-1,3-dihydro-5-phenyl-3-(2-thiomethyl)ethyl-2H-1,4-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 95 percent / acetyl bromide / benzene / 1 h / 20 °C

2: 56 percent / NaH / tetrahydrofuran; various solvent(s) / 4 h / 0 °C

With Acetyl bromide; sodium hydride; In tetrahydrofuran; benzene;
DOI:10.1021/ja0640142

Reference yield:

: 918159-87-2
(3S)-(-)-1-di(p-anisyl)methyl-7-chloro-1,3-dihydro-5-phenyl-3-(2-thiomethyl)ethyl-2H-1,4-benzodiazepin-2-one

: 19158-51-1
P-toluenesulfonyl cyanide

: (3R)-(-)-1-di(p-anisyl)methyl-7-chloro-3-cyano-1,3-dihydro-5-phenyl-3-(2-thiomethyl)ethyl-2H-1,4-benzodiazepin-2-one

: (3S)-1-di(p-anisyl)methyl-7-chloro-3-cyano-1,3-dihydro-5-phenyl-3-(2-thiomethyl)ethyl-2H-1,4-benzodiazepin-2-one

Guidance literature:: (3S)-(-)-1-di(p-anisyl)methyl-7-chloro-1,3-dihydro-5-phenyl-3-(2-thiomethyl)ethyl-2H-1,4-benzodiazepin-2-one; With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hexamethylsilazane; In 1,2-dimethoxyethane; toluene; at -42 ℃; for 0.5h;

P-toluenesulfonyl cyanide; With N,N,N,N,N,N-hexamethylphosphoric triamide; In 1,2-dimethoxyethane; toluene; at -42 ℃; for 0.5h; Title compound not separated from byproducts;
DOI:10.1021/ja0640142