69545-37-5

Basic information

• Product Name: Benzene, 1,1'-(bromomethylene)bis[4-methoxy-
• CAS NO: 69545-37-5
• Molecular Formula: C15H15BrO2
• Molecular Weight: 307.187
• Mol File: 69545-37-5.mol
• Article Data: 13

Chemical Properties

• CAS DataBase Reference: Benzene, 1,1'-(bromomethylene)bis[4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,1'-(bromomethylene)bis[4-methoxy-(69545-37-5)
• EPA Substance Registry System: Benzene, 1,1'-(bromomethylene)bis[4-methoxy-(69545-37-5)

Safety Data

• Hazardous Substances Data: 69545-37-5(Hazardous Substances Data)

Upstream product

• 46835-92-1 bis(p-methoxyphenyl)methyl cation 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 90-96-0 bis(p-methoxyphenyl)methanone 
• 116664-86-9 bis(4-methoxyphenyl)methyl 4-cyanophenyl ether 
• 42240-30-2 bis-(4-methoxyphenyl)methyl acetate 
• 728-87-0 4,4'-Dimethoxybenzhydrol 

Downstream Products

• 918160-16-4 (2R,11aR)-(+)-10-di(p-anisyl)methyl-2-tert-butyldimethylsilyloxy-2,3,5,10,11,11a-hexahydro-5,11-dioxo-1H-pyrrolo[2,1-c][1,4]benzodiazepine 
• 918159-87-2 (3S)-(-)-1-di(p-anisyl)methyl-7-chloro-1,3-dihydro-5-phenyl-3-(2-thiomethyl)ethyl-2H-1,4-benzodiazepin-2-one 
• 918159-86-1 (3S)-(+)-1-di(p-anisyl)methyl-7-chloro-3-ethyl-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one 
• 55681-26-0 α,α-bis(4-methoxyphenyl)acetophenone 
• 26608-02-6 bis(4-methoxyphenyl)methanethiol 
• 113650-85-4 4-(4,4'-dimethoxy-benzhydryloxy)-1,2,6-trimethyl-piperidine 
• 134311-00-5 4-(4-methoxyphenyl)-4-(4-methoxyphenyl)-1-butane 

Relevant articles and documents

Synthesis and biological evaluation of novel N-substituted nipecotic acid derivatives with an alkyne spacer as GABA uptake inhibitors

In this study, we present the synthesis and structure–activity relationships (SAR) of novel N-substituted nipecotic acid derivatives closely related to (S)-SNAP-5114 (2) in the pursuit of finding new and potent mGAT4 selective inhibitors. By the use of iminium ion chemistry, a series of new N-substituted nipecotic acid derivatives containing a variety of heterocycles, and an alkyne spacer were synthesized. Biological evaluation of the prepared compounds showed, how the inhibitory potency and subtype selectivity for the murine GABA transporters (mGATs) were influenced by the performed modifications.

Substituted diphenyl derivatives

Triazene-substituted diphenyl derivatives are suitable as chemotherapeutic agents for treating carcinomas in humans and animals.

Nucleofugality and nucleophilicity of fluoride in protic solvents

A series of p-substituted benzhydryl fluorides (diarylfluoromethanes) were prepared and subjected to solvolysis reactions, which were followed conductometrically. The observed first-order rate constants k1(25 °C) were found to follow the correlation equation log k1(25 °C) = sf(Nf + Ef), which allowed us to determine the nucleofuge-specific parameters Nf and sf for fluoride in different aqueous and alcoholic solvents. The rates of the reverse reactions were measured by generating benzhydrylium ions (diarylcarbenium ions) laser flash photolytically in various alcoholic and aqueous solvents in the presence of fluoride ions and monitoring the rate of consumption of the benzhydrylium ions by UV-vis spectroscopy. The resulting second-order rate constants k-1(20 °C) were substituted into the correlation equation log k-1 = sN(N + E) to derive the nucleophilicity parameters N and sN for fluoride in various protic solvents. Complete Gibbs energy profiles for the solvolysis reactions of benzhydryl fluorides are constructed.