N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

Base Information

Chemical Name:N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide
CAS No.:478921-21-0
Molecular Formula:C₄₈H₅₅F₃N₄O₈Si
Molecular Weight:901.067
Hs Code.:

<i>N</i>-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(<i>tert</i>-butyl-dimethyl-silanyloxy)-5-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

Synonyms:N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

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Chemical Property of N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

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Technology Process of N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

There total 4 articles about N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 383-63-1
ethyl trifluoroacetate,

: 478921-18-5
N-{1-[5-(2-azido-ethyl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide

: 478921-21-0
N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

Guidance literature:: With hydrogen; palladium on activated charcoal; In ethyl acetate; at 20 ℃; for 3h;
DOI:10.1016/S0968-0896(02)00141-4

Reference yield:

: 93-97-0
benzoic acid anhydride

: 478921-21-0
N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / pyridine / 24 h / 20 °C

2: 56 percent / H₂ / 10 percent Pd/C / ethyl acetate / 3 h / 20 °C

With pyridine; hydrogen; palladium on activated charcoal; In ethyl acetate;
DOI:10.1016/S0968-0896(02)00141-4

Reference yield:

: 267243-98-1
4'α-C-(2-azidoethyl)-3'-O-(tert-butyldimethylsilyl)-5'-O-(dimethoxytrityl)thymidine

: 478921-21-0
N-(1-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-5-[2-(2,2,2-trifluoro-acetylamino)-ethyl]-tetrahydro-furan-2-yl}-5-methyl-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: 2,4,6-triisopropylbenzenesulfonyl chloride; DMAP; Et₃N / acetonitrile / 1 h / 20 °C

1.2: 75 percent / conc. NH₄OH / acetonitrile / 2 h / 20 °C

2.1: 93 percent / pyridine / 24 h / 20 °C

3.1: 56 percent / H₂ / 10 percent Pd/C / ethyl acetate / 3 h / 20 °C

With pyridine; dmap; 2,4,6-triisopropylphenylsulfonyl chloride; hydrogen; triethylamine; palladium on activated charcoal; In ethyl acetate; acetonitrile;
DOI:10.1016/S0968-0896(02)00141-4