2'-deoxy-5'-O-(dimethoxytrityl)-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite]

Base Information

• Chemical Name: 2'-deoxy-5'-O-(dimethoxytrityl)-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite]
• CAS No.: 153120-94-6
• Molecular Formula: C₆₀H₆₂N₇O₁₀P
• Molecular Weight: 1072.17

Synonyms:2'-deoxy-5'-O-(dimethoxytrityl)-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite]

Chemical Property of 2'-deoxy-5'-O-(dimethoxytrityl)-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite]

Chemical Property:

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Technology Process of 2'-deoxy-5'-O-(dimethoxytrityl)-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite]

There total 3 articles about 2'-deoxy-5'-O-(dimethoxytrityl)-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite] which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2'-deoxy-5'-O-(dimethoxytrityl)-N6-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine (109389-32-4) + 2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite (153120-90-2) → 2'-deoxy-5'-O-(dimethoxytrityl)-N6-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite] (153120-94-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.5h;

DOI:10.1002/hlca.200390186

Reference yield:

4,4'-dimethoxytrityl chloride (40615-36-9) → 2'-deoxy-5'-O-(dimethoxytrityl)-N6-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite] (153120-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / pyridine / 18 h / 20 °C

2: 70 percent / EtiPr₂N / CH₂Cl₂ / 1.5 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1002/hlca.200390186

Reference yield:

2'-deoxy-N6-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine (87424-20-2) → 2'-deoxy-5'-O-(dimethoxytrityl)-N6-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine 3'-[2-(4-nitrophenyl)ethyl diisopropylphosphoramidite] (153120-94-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / pyridine / 18 h / 20 °C

2: 70 percent / EtiPr₂N / CH₂Cl₂ / 1.5 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane;

DOI:10.1002/hlca.200390186

upstream raw materials:

2'-deoxy-5'-O-(dimethoxytrityl)-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine

2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite

4,4'-dimethoxytrityl chloride

2'-deoxy-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]adenosine

Downstream raw materials:

2'-deoxy-5'-O-(dimethoxytrityl)-N⁶-[(9H-fluoren-9-ylmethoxy)carbonyl]adenylyl-{3'-{O^P-[2-(4-nitrophenyl)ethyl]}-5'}-2'-deoxy-N⁶,3'-O-bis{[2-(4-nitrophenyl)ethoxy]carbonyl}adenosine

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