bis((4S,5S)-5-phenyl-4-((4,6,7,9-tetrahydro-1H-[1,4]dithiocino[6,7-d][1,2,3]triazol-1-yl)methyl)-4,5-dihydrooxazol-2-yl)methane

Base Information

Chemical Name:bis((4S,5S)-5-phenyl-4-((4,6,7,9-tetrahydro-1H-[1,4]dithiocino[6,7-d][1,2,3]triazol-1-yl)methyl)-4,5-dihydrooxazol-2-yl)methane
CAS No.:1453106-71-2
Molecular Formula:C₃₃H₃₆N₈O₂S₄
Molecular Weight:704.965
Hs Code.:

Synonyms:bis((4S,5S)-5-phenyl-4-((4,6,7,9-tetrahydro-1H-[1,4]dithiocino[6,7-d][1,2,3]triazol-1-yl)methyl)-4,5-dihydrooxazol-2-yl)methane

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Chemical Property of bis((4S,5S)-5-phenyl-4-((4,6,7,9-tetrahydro-1H-[1,4]dithiocino[6,7-d][1,2,3]triazol-1-yl)methyl)-4,5-dihydrooxazol-2-yl)methane

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Technology Process of bis((4S,5S)-5-phenyl-4-((4,6,7,9-tetrahydro-1H-[1,4]dithiocino[6,7-d][1,2,3]triazol-1-yl)methyl)-4,5-dihydrooxazol-2-yl)methane

There total 4 articles about bis((4S,5S)-5-phenyl-4-((4,6,7,9-tetrahydro-1H-[1,4]dithiocino[6,7-d][1,2,3]triazol-1-yl)methyl)-4,5-dihydrooxazol-2-yl)methane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1453106-63-2
bis((4S,5S)-4-(azidomethyl)-5-phenyl-4,5-dihydrooxazol-2-yl)methane

: 153615-58-8
1,4-dithia-6-cyclooctyne

: 1453106-71-2
bis((4S,5S)-5-phenyl-4-((4,6,7,9-tetrahydro-1H-[1,4]dithiocino[6,7-d][1,2,3]triazol-1-yl)methyl)-4,5-dihydrooxazol-2-yl)methane

Guidance literature:: In dichloromethane; at 40 ℃; for 48h; Inert atmosphere; Schlenk technique; Sealed tube;
DOI:10.1002/ejoc.201300279

Reference yield:

: 10344-69-1
diethyl malonoimidate dihydrochloride

: 1453106-71-2
bis((4S,5S)-5-phenyl-4-((4,6,7,9-tetrahydro-1H-[1,4]dithiocino[6,7-d][1,2,3]triazol-1-yl)methyl)-4,5-dihydrooxazol-2-yl)methane

Guidance literature:: Multi-step reaction with 4 steps

1: dichloromethane / 18 h / Inert atmosphere; Schlenk technique; Reflux

2: carbon tetrabromide; triphenylphosphine / dichloromethane / 16 h / 20 °C / Inert atmosphere; Schlenk technique

3: sodium azide / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere; Schlenk technique

4: dichloromethane / 48 h / 40 °C / Inert atmosphere; Schlenk technique; Sealed tube

With sodium azide; carbon tetrabromide; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201300279

Reference yield:

: 133463-87-3
(-)-(4S,4'S,5S,5'S)-4,4',5,5'-Tetrahydro-2,2'-methylene-5,5'-diphenylbis-4,4'-di(methanol)

: 1453106-71-2
bis((4S,5S)-5-phenyl-4-((4,6,7,9-tetrahydro-1H-[1,4]dithiocino[6,7-d][1,2,3]triazol-1-yl)methyl)-4,5-dihydrooxazol-2-yl)methane

Guidance literature:: Multi-step reaction with 3 steps

1: carbon tetrabromide; triphenylphosphine / dichloromethane / 16 h / 20 °C / Inert atmosphere; Schlenk technique

2: sodium azide / N,N-dimethyl-formamide / 12 h / 50 °C / Inert atmosphere; Schlenk technique

3: dichloromethane / 48 h / 40 °C / Inert atmosphere; Schlenk technique; Sealed tube

With sodium azide; carbon tetrabromide; triphenylphosphine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/ejoc.201300279