4-isopropylfuran-2-carbaldehyde

Base Information

• Chemical Name: 4-isopropylfuran-2-carbaldehyde
• CAS No.: 16015-07-9
• Molecular Formula: C8H10 O2
• Molecular Weight: 138.166
• Hs Code.: 2932190090
• Mol file: 16015-07-9.mol

Synonyms:2-Furaldehyde,4-isopropyl- (8CI); 4-Isopropylfuran-2-carboxaldehyde

Chemical Property of 4-isopropylfuran-2-carbaldehyde

Chemical Property:

• Boiling Point: 92-95 °C(Press: 13 Torr)
• PSA: 30.21000
• Density: 1.031±0.06 g/cm3(Predicted)
• LogP: 2.21550
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

4-Isopropylfuran-2-carbaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-isopropylfuran-2-carbaldehyde

There total 7 articles about 4-isopropylfuran-2-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(4-isopropyl-furan-2-yl)-methanol (59413-65-9) → 4-Isopropyl-2-furaldehyde (16015-07-9)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; for 0.5h;

Reference yield: 20.0%

furfural (98-01-1) + isopropyl chloride (75-29-6) → 4-Isopropyl-2-furaldehyde (16015-07-9)

Guidance literature:

With aluminium trichloride; In carbon disulfide; at 20 ℃; for 24h;

DOI:10.1021/jo010020z

Reference yield:

4-isopropyl-furan-2-carboxylic acid methyl ester (38071-65-7) → 4-Isopropyl-2-furaldehyde (16015-07-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / LiAlH₄ / tetrahydrofuran / 3 h / 0 - 20 °C

2: 78 percent / Dess-Martin periodinane / CH₂Cl₂ / 3 h / 20 °C

With lithium aluminium tetrahydride; Dess-Martin periodane; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2007.04.016

upstream raw materials:

furfural

isopropyl chloride

aluminium trichloride

(4-isopropyl-furan-2-yl)-methanol

Downstream raw materials:

C₁₃H₂₁NO₂

C₁₂H₂₁NO

C₁₁H₁₉NO

C₉H₁₅NO

Refernces

• 1、 Chao, Jianhua,Taveras, Arthur G.,Chao, Jianping,Aki, Cynthia,Dwyer, Michael,Yu, Younong,Purakkattle, Biju,Rindgen, Diane,Jakway, James,Hipkin, William,Fosetta, James,Fan, Xuedong,Lundell, Daniel,Fine, Jay,Minnicozzi, Michael,Phillips, Jonathan,Merritt, J. Robert. "C(4)-alkyl substituted furanyl cyclobutenediones as potent, orally bioavailable CXCR2 and CXCR1 receptor antagonists". . p. 3778 - 3783. Retrieved 2008/02/10.
• 2、 -. "3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands". Page 124-125. . Retrieved 2008/06/13.