(R)-2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(triisopropylsilyloxy)propan-1-ol

Base Information

Chemical Name:(R)-2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(triisopropylsilyloxy)propan-1-ol
CAS No.:1589000-86-1
Molecular Formula:C₂₀H₃₅BrO₅Si
Molecular Weight:463.484
Hs Code.:

Synonyms:(R)-2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(triisopropylsilyloxy)propan-1-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(triisopropylsilyloxy)propan-1-ol

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Technology Process of (R)-2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(triisopropylsilyloxy)propan-1-ol

There total 6 articles about (R)-2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(triisopropylsilyloxy)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1589000-84-9
(R)-{2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(4''-methoxybenzyloxy)propoxy}triisopropylsilane

: 1589000-86-1
(R)-2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(triisopropylsilyloxy)propan-1-ol

Guidance literature:: With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; water; at 20 ℃; for 1.5h; Inert atmosphere;
DOI:10.1002/ejoc.201301363

Reference yield:

: 1589001-06-8
(S)-1-(triisopropylsilyloxy)-3-(4-methoxybenzyloxy)propan-2-ol

: 1589000-86-1
(R)-2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(triisopropylsilyloxy)propan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 72 h / 0 - 20 °C / Inert atmosphere

2: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 1.5 h / 20 °C / Inert atmosphere

With di-isopropyl azodicarboxylate; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water; 1: |Mitsunobu Displacement;
DOI:10.1002/ejoc.201301363

Reference yield:

: 90-02-8
salicylaldehyde

: 1589000-86-1
(R)-2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(triisopropylsilyloxy)propan-1-ol

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 20 °C / Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 72 h / 0 - 20 °C / Inert atmosphere

5.1: 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane; water / 1.5 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; 4.1: |Mitsunobu Displacement;
DOI:10.1002/ejoc.201301363