(R)-{2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(4''-methoxybenzyloxy)propoxy}triisopropylsilane

Base Information

Chemical Name:(R)-{2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(4''-methoxybenzyloxy)propoxy}triisopropylsilane
CAS No.:1589000-84-9
Molecular Formula:C₂₈H₄₃BrO₆Si
Molecular Weight:583.635
Hs Code.:

Synonyms:(R)-{2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(4''-methoxybenzyloxy)propoxy}triisopropylsilane

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Chemical Property of (R)-{2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(4''-methoxybenzyloxy)propoxy}triisopropylsilane

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Technology Process of (R)-{2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(4''-methoxybenzyloxy)propoxy}triisopropylsilane

There total 6 articles about (R)-{2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(4''-methoxybenzyloxy)propoxy}triisopropylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 1589001-06-8
(S)-1-(triisopropylsilyloxy)-3-(4-methoxybenzyloxy)propan-2-ol

: 1589000-58-7
4-bromo-2-(methoxymethoxy)phenol

: 1589000-84-9
(R)-{2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(4''-methoxybenzyloxy)propoxy}triisopropylsilane

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 72h; Inert atmosphere;
DOI:10.1002/ejoc.201301363

Reference yield:

: 109786-74-5
(R)-3-(4-methoxybenzyloxy)propane-1,2-diol

: 1589000-84-9
(R)-{2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(4''-methoxybenzyloxy)propoxy}triisopropylsilane

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 22 h / 20 °C / Inert atmosphere

2: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 72 h / 0 - 20 °C / Inert atmosphere

With 1H-imidazole; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; N,N-dimethyl-formamide; 2: |Mitsunobu Displacement;
DOI:10.1002/ejoc.201301363

Reference yield:

: 90-02-8
salicylaldehyde

: 1589000-84-9
(R)-{2-[4'-bromo-2'-(methoxymethoxy)phenoxy]-3-(4''-methoxybenzyloxy)propoxy}triisopropylsilane

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C / Inert atmosphere

2.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 48 h / 20 °C / Inert atmosphere

2.2: 5 h / 20 °C / Inert atmosphere

3.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

4.1: di-isopropyl azodicarboxylate; triphenylphosphine / tetrahydrofuran / 72 h / 0 - 20 °C / Inert atmosphere

With N-Bromosuccinimide; di-isopropyl azodicarboxylate; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; 4.1: |Mitsunobu Displacement;
DOI:10.1002/ejoc.201301363