C₃₂H₃₈N₂O₅

Base Information

• Chemical Name: C₃₂H₃₈N₂O₅
• CAS No.: 1422740-24-6
• Molecular Formula: C₃₂H₃₈N₂O₅
• Molecular Weight: 530.664
• Mol file: 1422740-24-6.mol

Synonyms:C₃₂H₃₈N₂O₅

Chemical Property of C₃₂H₃₈N₂O₅

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₂H₃₈N₂O₅

There total 15 articles about C₃₂H₃₈N₂O₅ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H32N2O5 + benzyl bromide (100-39-0) → C32H38N2O5 (1422740-24-6)

Guidance literature:

With silver(l) oxide; In ethyl acetate; at 20 ℃; for 16h;

DOI:10.3762/bjoc.8.210

Reference yield:

tert-butyl (S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-oxopyrrolidin-1-carboxylate (81658-26-6) → C32H38N2O5 (1422740-24-6)

Guidance literature:

Multi-step reaction with 14 steps

1.1: sodium methylate / methanol / 0.17 h / 20 °C

2.1: toluene-4-sulfonic acid / methanol / 3 h / 20 °C

3.1: boron trifluoride diethyl etherate; 2,2-dimethoxy-propane / 0.5 h / 20 °C

4.1: N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

4.2: 3 h / -78 °C

5.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / -40 °C

6.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / 0 °C

7.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 24 h / 20 °C

8.1: triethylamine / dichloromethane / 24 h / 0 - 20 °C

9.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

9.2: 72 h / 20 °C

10.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 20 °C

11.1: pyridine / 0.67 h / 0 °C

12.1: sodium hydrogencarbonate / dimethyl sulfoxide / 8 h / 60 °C

13.1: toluene-4-sulfonic acid / methanol / 6 h / 20 °C

14.1: silver(l) oxide / ethyl acetate / 16 h / 20 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; osmium(VIII) oxide; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium methylate; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; 2,2-dimethoxy-propane; silver(l) oxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; toluene; mineral oil; tert-butyl alcohol; 5.1: |Wittig-Horner Reaction;

DOI:10.3762/bjoc.8.210

Reference yield:

Methyl (4S)-4-(N-(tert-Butoxycarbonyl)amino)-5-((tert-butyldimethylsilyl)oxy)pentanoate (96014-55-0) → C32H38N2O5 (1422740-24-6)

Guidance literature:

Multi-step reaction with 13 steps

1.1: toluene-4-sulfonic acid / methanol / 3 h / 20 °C

2.1: boron trifluoride diethyl etherate; 2,2-dimethoxy-propane / 0.5 h / 20 °C

3.1: N,N,N,N,N,N-hexamethylphosphoric triamide; n-butyllithium; diisopropylamine / tetrahydrofuran / 0.5 h / -78 °C

3.2: 3 h / -78 °C

4.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / -40 °C

5.1: diisobutylaluminium hydride / tetrahydrofuran; toluene / 1 h / 0 °C

6.1: osmium(VIII) oxide; 4-methylmorpholine N-oxide / water; tert-butyl alcohol / 24 h / 20 °C

7.1: triethylamine / dichloromethane / 24 h / 0 - 20 °C

8.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

8.2: 72 h / 20 °C

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1.5 h / 0 - 20 °C

10.1: pyridine / 0.67 h / 0 °C

11.1: sodium hydrogencarbonate / dimethyl sulfoxide / 8 h / 60 °C

12.1: toluene-4-sulfonic acid / methanol / 6 h / 20 °C

13.1: silver(l) oxide / ethyl acetate / 16 h / 20 °C

With pyridine; N,N,N,N,N,N-hexamethylphosphoric triamide; osmium(VIII) oxide; n-butyllithium; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; sodium hydride; diisobutylaluminium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; 4-methylmorpholine N-oxide; triethylamine; diisopropylamine; 3-chloro-benzenecarboperoxoic acid; 2,2-dimethoxy-propane; silver(l) oxide; In tetrahydrofuran; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; toluene; mineral oil; tert-butyl alcohol; 4.1: |Wittig-Horner Reaction;

DOI:10.3762/bjoc.8.210

upstream raw materials:

C₁₉H₃₉NO₆Si

Methyl (4S)-4-(N-(tert-Butoxycarbonyl)amino)-5-((tert-butyldimethylsilyl)oxy)pentanoate

(4S)-4-(2-methoxycarbonylethyl)-2,2-dimethyloxazolidine-3-carboxylic acid tert-butyl ester

tert-butyl (S)-2-(((tert-butyldimethylsilyl)oxy)methyl)-5-oxopyrrolidin-1-carboxylate

Downstream raw materials:

C₃₂H₃₉NO₆

C₃₅H₄₃NO₅

C₃₅H₄₃NO₅