N-desisopropylpropranolol

Base Information

• Chemical Name: N-desisopropylpropranolol
• CAS No.: 30200-48-7
• Molecular Formula: C₁₃H₁₅NO₂
• Molecular Weight: 217.268
• Mol file: 30200-48-7.mol

Synonyms:N-desisopropylpropranolol

Chemical Property of N-desisopropylpropranolol

Chemical Property:

Purity/Quality:

>95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-desisopropylpropranolol

There total 6 articles about N-desisopropylpropranolol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

Acetic acid (S)-1-cyano-2-(naphthalen-1-yloxy)-ethyl ester (104730-52-1,104760-42-1,123356-15-0) → (S)-1-Amino-3-(naphthalen-1-yloxy)-propan-2-ol (20862-11-7,30200-48-7,88547-38-0,88547-39-1)

Guidance literature:

With lithium aluminium tetrahydride;

DOI:10.1016/S0040-4039(01)80880-7

Reference yield:

Inderal (318-98-9) → 4-hydroxypropranolol (10476-53-6,69499-28-1,76792-96-6,76792-97-7) + N-desisopropylpropranolol (30200-48-7) + α-Naphthoxylactic acid (10476-54-7) + 5-Hydroxypropranolol (81907-82-6,111691-89-5)

Guidance literature:

metabolism in the isolated perfused nonfasted male Sprague-Dawley rat liver;

DOI:10.1002/jps.2600830704

Reference yield:

α-naphthol (90-15-3) → (S)-1-Amino-3-(naphthalen-1-yloxy)-propan-2-ol (20862-11-7,30200-48-7,88547-38-0,88547-39-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 60 percent / K₂CO₃ / dimethylformamide / 10 h / 100 °C

2: HCl-AcOH

3: TBAB

4: 79.4 percent / lipase (Pseudomonas sp.) / 24 h / 40 °C / pH 5

5: 81 percent / LAH

With hydrogenchloride; lithium aluminium tetrahydride; potassium carbonate; acetic acid; lipase (Pseudomonas sp.); tetrabutylammomium bromide; In N,N-dimethyl-formamide;

DOI:10.1016/S0040-4039(01)80880-7

upstream raw materials:

Inderal

Acetic acid (S)-1-cyano-2-(naphthalen-1-yloxy)-ethyl ester

α-naphthol

2-(1-naphthoxy)acetaldehyde diethyl acetal

Downstream raw materials:

1-(naphthalen-1-yloxy)-3-(piperidin-1-yl)propan-2-ol

N-<2-Chlor-3-(1-naphthyloxy)>propylbenzamid

1-(1,1,1,2,3,3,3-heptadeutero-2-propylamino)-3-(1-naphthoxy)-2-propanol

(S)-(-)-propanolol