dibutyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

Base Information

Chemical Name:dibutyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate
CAS No.:1415231-07-0
Molecular Formula:C₂₄H₃₃ClN₂O₅
Molecular Weight:464.989
Hs Code.:

Synonyms:dibutyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

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Chemical Property of dibutyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

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Technology Process of dibutyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

There total 2 articles about dibutyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 141-32-2,9003-49-0
acrylic acid n-butyl ester

: 1412907-25-5
1-(4-chlorophenyl)-3-methyl-1H-pyrazol-5-yl acetate

: 1415230-91-9
butyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

: 1415231-07-0
dibutyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/j.tetlet.2012.09.096

Reference yield:

: 1073-70-7
4-chlorophenylhydrazine hydrochloride

: 1415230-91-9
butyl 3-(5-acetoxy-1-(4-chlorophenyl)-3-methyl-1H-pyrazol-4-yl)propanoate

: 1415231-07-0
dibutyl 3,3'-(1-(4-chlorophenyl)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazole-4,4-diyl)dipropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / ethanol / 24 h / 60 °C / Reflux

2: 12 h / 20 °C

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 24 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; In ethanol; dichloromethane; 3: |Michael Addition;
DOI:10.1016/j.tetlet.2012.09.096