(S)-benzyl (1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

Base Information

Chemical Name:(S)-benzyl (1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate
CAS No.:1609191-00-5
Molecular Formula:C₂₉H₃₃N₅O₄
Molecular Weight:515.612
Hs Code.:

Synonyms:(S)-benzyl (1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

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Chemical Property of (S)-benzyl (1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

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Technology Process of (S)-benzyl (1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

There total 4 articles about (S)-benzyl (1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: (S)-3-(2-(1-(((benzyloxy)carbonyl)amino)-6-carboxyhexyl)-1H-imidazol-3-ium-5-yl)-2-methoxyquinolin-1-ium bis trifluoroacetate

: 74-89-5
methylamine

: 1609191-00-5
(S)-benzyl (1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

Guidance literature:: (S)-3-(2-(1-(((benzyloxy)carbonyl)amino)-6-carboxyhexyl)-1H-imidazol-3-ium-5-yl)-2-methoxyquinolin-1-ium bis trifluoroacetate; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

methylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/acsmedchemlett.5b00468

Reference yield:

: 49645-27-4
(S)-2-(((benzyloxy)carbonyl)amino)-8-(tert-butoxy)-8-oxooctanoic acid

: 1609191-00-5
(S)-benzyl (1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h

1.2: 16 h / 20 °C

1.3: 1.5 h / Dean-Stark; Heating

2.1: trifluoroacetic acid / dichloromethane / 24 h / 0 - 4 °C

3.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1125845-79-5
2-hydroxy-1-(2-methoxyquinolin-3-yl)ethan-1-one

: 1609191-00-5
(S)-benzyl (1-(5-(2-methoxyquinolin-3-yl)-1H-imidazol-2-yl)-7-(methylamino)-7-oxoheptyl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.25 h

1.2: 16 h / 20 °C

1.3: 1.5 h / Dean-Stark; Heating

2.1: trifluoroacetic acid / dichloromethane / 24 h / 0 - 4 °C

3.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide; tetrahydrofuran / 1 h / 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;