Technology Process of 4-((3,4-dichlorophenoxy)methyl)-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt
There total 6 articles about 4-((3,4-dichlorophenoxy)methyl)-2,5-difluoro-N-(methylsulfonyl)benzamide diethylamine salt which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
4-((3,4-dichlorophenoxy)methyl)-2,5-difluorobenzamide;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran;
for 0.283333 - 0.366667h;
methanesulfonyl chloride;
In
tetrahydrofuran;
at 20 ℃;
for 18h;
diethylamine;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: n-butyllithium / tetrahydrofuran; hexanes / 0.5 h / -78 °C
1.2: -78 - 20 °C / Inert atmosphere
1.3: 5 h
2.1: sodium tetrahydroborate; ethanol / 5 h / 0 - 5 °C
3.1: phosphorus tribromide / dichloromethane / 18 h / 20 °C
4.1: potassium carbonate / acetone / 36 h / 20 °C
5.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 3 h
6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.28 - 0.37 h
6.2: 18 h / 20 °C
With
sodium tetrahydroborate; n-butyllithium; ethanol; dihydrogen peroxide; phosphorus tribromide; potassium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; hexanes; dichloromethane; water; dimethyl sulfoxide; acetone;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium tetrahydroborate; ethanol / 5 h / 0 - 5 °C
2.1: phosphorus tribromide / dichloromethane / 18 h / 20 °C
3.1: potassium carbonate / acetone / 36 h / 20 °C
4.1: dihydrogen peroxide; potassium carbonate / water; dimethyl sulfoxide / 3 h
5.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.28 - 0.37 h
5.2: 18 h / 20 °C
With
sodium tetrahydroborate; ethanol; dihydrogen peroxide; phosphorus tribromide; potassium carbonate; lithium hexamethyldisilazane;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; acetone;
