Methanesulfonic acid 2-[(2-methanesulfonyloxy-ethyl)-(4-nitro-benzenesulfonyl)-amino]-ethyl ester

Base Information

• Chemical Name: Methanesulfonic acid 2-[(2-methanesulfonyloxy-ethyl)-(4-nitro-benzenesulfonyl)-amino]-ethyl ester
• CAS No.: 188444-62-4
• Molecular Formula: C₁₂H₁₈N₂O₁₀S₃
• Molecular Weight: 446.48
• Mol file: 188444-62-4.mol

Synonyms:Methanesulfonic acid 2-[(2-methanesulfonyloxy-ethyl)-(4-nitro-benzenesulfonyl)-amino]-ethyl ester

Chemical Property of Methanesulfonic acid 2-[(2-methanesulfonyloxy-ethyl)-(4-nitro-benzenesulfonyl)-amino]-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Methanesulfonic acid 2-[(2-methanesulfonyloxy-ethyl)-(4-nitro-benzenesulfonyl)-amino]-ethyl ester

There total 1 articles about Methanesulfonic acid 2-[(2-methanesulfonyloxy-ethyl)-(4-nitro-benzenesulfonyl)-amino]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

4-nitro-N,N-bis(2-hydroxyethyl)benzenesulfonamide (18226-07-8) + methanesulfonyl chloride (124-63-0) → Methanesulfonic acid 2-[(2-methanesulfonyloxy-ethyl)-(4-nitro-benzenesulfonyl)-amino]-ethyl ester (188444-62-4)

Guidance literature:

With triethylamine; In dichloromethane; for 48h; Ambient temperature;

DOI:10.1016/S0968-0896(96)00202-7

Reference yield: 53.0%

β-naphthol (135-19-3) + Methanesulfonic acid 2-[(2-methanesulfonyloxy-ethyl)-(4-nitro-benzenesulfonyl)-amino]-ethyl ester (188444-62-4) → Methanesulfonic acid 2-[[2-(naphthalen-2-yloxy)-ethyl]-(4-nitro-benzenesulfonyl)-amino]-ethyl ester (188444-63-5)

Guidance literature:

With potassium hydroxide; In N,N-dimethyl-formamide; acetone; at 75 ℃; for 15h;

DOI:10.1016/S0968-0896(96)00202-7

Reference yield:

Methanesulfonic acid 2-[(2-methanesulfonyloxy-ethyl)-(4-nitro-benzenesulfonyl)-amino]-ethyl ester (188444-62-4) → N-[2-(2-Amino-6-oxo-1,6-dihydro-purin-9-yl)-ethyl]-4-hydroxyamino-N-[2-(naphthalen-2-yloxy)-ethyl]-benzenesulfonamide

Guidance literature:

Multi-step reaction with 4 steps

1: 53 percent / aq. KOH / acetone; dimethylformamide / 15 h / 75 °C

2: 55 percent / K₂CO₃ / dimethylformamide / 48 h / 85 °C

3: 90 percent / HCl, AcOH / dimethylformamide; methanol / 72 h / Ambient temperature

4: 92 percent / H₂ / 10percent Pd/C / dimethylformamide / 6 h / 3102.9 Torr

With hydrogenchloride; potassium hydroxide; hydrogen; potassium carbonate; acetic acid; palladium on activated charcoal; In methanol; N,N-dimethyl-formamide; acetone;

DOI:10.1016/S0968-0896(96)00202-7

upstream raw materials:

4-nitro-N,N-bis(2-hydroxyethyl)benzenesulfonamide

methanesulfonyl chloride

Downstream raw materials:

Methanesulfonic acid 2-[[2-(naphthalen-2-yloxy)-ethyl]-(4-nitro-benzenesulfonyl)-amino]-ethyl ester

4-nitro-N-[2-(2-naphthyloxy)ethyl]-N-[2-(2-amino-6-chloro-9H-purin-9-yl)ethyl]benzenesulfonamide

4-nitro-N-[2-(2-naphthyloxy)ethyl]-N-[2-(2-amino-1,9-dihydro-6-oxo-6H-purin-9-yl)ethyl]benzenesulfonamide