tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)thio)methyl)-tetrahydro-2H-pyran-3-yl)carbamate

Base Information

Chemical Name:tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)thio)methyl)-tetrahydro-2H-pyran-3-yl)carbamate
CAS No.:881657-48-3
Molecular Formula:C₁₈H₂₅N₅O₃S
Molecular Weight:391.494
Hs Code.:

Synonyms:tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)thio)methyl)-tetrahydro-2H-pyran-3-yl)carbamate

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Chemical Property of tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)thio)methyl)-tetrahydro-2H-pyran-3-yl)carbamate

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Technology Process of tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)thio)methyl)-tetrahydro-2H-pyran-3-yl)carbamate

There total 6 articles about tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)thio)methyl)-tetrahydro-2H-pyran-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 881657-58-5
tert-butyl ((3R,6S)-6-(iodomethyl)tetrahydro-2H-pyran-3-yl)carbamate

: 86-93-1
1-Phenyl-1H-tetrazole-5-thiol

: 881657-48-3
tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)thio)methyl)-tetrahydro-2H-pyran-3-yl)carbamate

Guidance literature:: With potassium hydroxide; In ethanol; for 1h; Heating / reflux;

Reference yield:

: 603130-11-6
(2S,5R)-5-[(tert-butoxycarbonyl)amino]-2-[(tert-butyldimethylsilanyloxy)methyl]-2,5-dihydro-6H-pyran

: 881657-48-3
tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)thio)methyl)-tetrahydro-2H-pyran-3-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; acetic acid / tetrahydrofuran / 5 h / 70 °C

2.1: hydrogen / platinum(IV) oxide / ethyl acetate / 3 h

3.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C

4.1: sodium iodide / acetone / 24 h / Heating / reflux

5.1: potassium hydroxide / ethanol / 1 h / Heating / reflux

5.2: Heating / reflux

With dmap; potassium hydroxide; water; hydrogen; acetic acid; triethylamine; sodium iodide; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; ethyl acetate; acetone;

Reference yield:

: 881656-86-6
tert-butyl ((3R,6S)-6-(hydroxymethyl)-3,6-dihydro-2H-pyran-3-yl)carbamate

: 881657-48-3
tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)thio)methyl)-tetrahydro-2H-pyran-3-yl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen / platinum(IV) oxide / ethyl acetate / 3 h

2.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C

3.1: sodium iodide / acetone / 24 h / Heating / reflux

4.1: potassium hydroxide / ethanol / 1 h / Heating / reflux

4.2: Heating / reflux

With dmap; potassium hydroxide; hydrogen; triethylamine; sodium iodide; platinum(IV) oxide; In ethanol; dichloromethane; ethyl acetate; acetone;