tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)sulfonyl)-methyl)tetrahydro-2H-pyran-3-yl)carbamate

Base Information

Chemical Name:tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)sulfonyl)-methyl)tetrahydro-2H-pyran-3-yl)carbamate
CAS No.:881657-49-4
Molecular Formula:C₁₈H₂₅N₅O₅S
Molecular Weight:423.493
Hs Code.:

Synonyms:tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)sulfonyl)-methyl)tetrahydro-2H-pyran-3-yl)carbamate

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Chemical Property of tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)sulfonyl)-methyl)tetrahydro-2H-pyran-3-yl)carbamate

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Technology Process of tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)sulfonyl)-methyl)tetrahydro-2H-pyran-3-yl)carbamate

There total 7 articles about tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)sulfonyl)-methyl)tetrahydro-2H-pyran-3-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 881657-48-3
tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)thio)methyl)-tetrahydro-2H-pyran-3-yl)carbamate

: 881657-49-4
tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)sulfonyl)-methyl)tetrahydro-2H-pyran-3-yl)carbamate

Guidance literature:: With hexaammonium heptamolybdate tetrahydrate; dihydrogen peroxide; In tetrahydrofuran; ethanol; water; at 20 - 65 ℃; for 3h;
DOI:10.1021/jm400963y

Reference yield:

: 881656-86-6
tert-butyl ((3R,6S)-6-(hydroxymethyl)-3,6-dihydro-2H-pyran-3-yl)carbamate

: 881657-49-4
tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)sulfonyl)-methyl)tetrahydro-2H-pyran-3-yl)carbamate

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / platinum(IV) oxide / ethyl acetate / 3 h

2.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C

3.1: sodium iodide / acetone / 24 h / Heating / reflux

4.1: potassium hydroxide / ethanol / 1 h / Heating / reflux

4.2: Heating / reflux

5.1: ammonium heptamolybdate; dihydrogen peroxide / tetrahydrofuran; ethanol; water / 3 h / 20 - 65 °C

With dmap; ammonium heptamolybdate; potassium hydroxide; hydrogen; dihydrogen peroxide; triethylamine; sodium iodide; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; acetone;

Reference yield:

: 603130-11-6
(2S,5R)-5-[(tert-butoxycarbonyl)amino]-2-[(tert-butyldimethylsilanyloxy)methyl]-2,5-dihydro-6H-pyran

: 881657-49-4
tert-butyl ((3R,6S)-6-(((1-phenyl-1H-tetrazol-5-yl)sulfonyl)-methyl)tetrahydro-2H-pyran-3-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: water; acetic acid / tetrahydrofuran / 5 h / 70 °C

2.1: hydrogen / platinum(IV) oxide / ethyl acetate / 3 h

3.1: dmap; triethylamine / dichloromethane / 4 h / 0 - 20 °C

4.1: sodium iodide / acetone / 24 h / Heating / reflux

5.1: potassium hydroxide / ethanol / 1 h / Heating / reflux

5.2: Heating / reflux

6.1: ammonium heptamolybdate; dihydrogen peroxide / tetrahydrofuran; ethanol; water / 3 h / 20 - 65 °C

With dmap; ammonium heptamolybdate; potassium hydroxide; water; hydrogen; dihydrogen peroxide; acetic acid; triethylamine; sodium iodide; platinum(IV) oxide; In tetrahydrofuran; ethanol; dichloromethane; water; ethyl acetate; acetone;