6-chloro-4-(5-{[(2R,6R)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

Base Information

Chemical Name:6-chloro-4-(5-{[(2R,6R)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole
CAS No.:1254036-91-3
Molecular Formula:C₂₃H₂₃ClN₄O₄S
Molecular Weight:486.979
Hs Code.:

Synonyms:6-chloro-4-(5-{[(2R,6R)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

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Chemical Property of 6-chloro-4-(5-{[(2R,6R)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

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Technology Process of 6-chloro-4-(5-{[(2R,6R)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

There total 9 articles about 6-chloro-4-(5-{[(2R,6R)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141-91-3
2,6-dimethyl morpholine

: 1254036-84-4
4-[5-(bromomethyl)-1,3-oxazol-2-yl]-6-chloro-1-(phenylsulfonyl)-1H-indazole

: 1254036-91-3
6-chloro-4-(5-{[(2R,6R)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

Guidance literature:: With air; In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 141-91-3
2,6-dimethyl morpholine

: 1254036-84-4
4-[5-(bromomethyl)-1,3-oxazol-2-yl]-6-chloro-1-(phenylsulfonyl)-1H-indazole

: 1254036-85-5,1364801-65-9
6-chloro-4-(5-{[(2R,6S)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

: 1254036-91-3
6-chloro-4-(5-{[(2R,6R)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

Guidance literature:: In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 885519-56-2
6-chloro-4-iodo-1H-indazole

: 1254036-91-3
6-chloro-4-(5-{[(2R,6R)-2,6-dimethyl-4-morpholinyl]methyl}-1,3-oxazol-2-yl)-1-(phenylsulfonyl)-1H-indazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: benzenesulfonyl chloride; sodium hydride / N,N-dimethyl-formamide / 0.33 h / 10 °C / Inert atmosphere

1.2: 10 - 20 °C

2.1: zinc(II) chloride; lithium hexamethyldisilazane / tetrahydrofuran / 1.25 h / -10 °C / Inert atmosphere

2.2: 60 °C / Inert atmosphere

2.3: 0 - 5 °C

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 0 - 20 °C

4.1: air / dichloromethane / 20 h / 20 °C

With carbon tetrabromide; sodium hydride; benzenesulfonyl chloride; triphenylphosphine; zinc(II) chloride; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;