Technology Process of 4-[5-(bromomethyl)-2-oxazolyl]-6-chloro-1-(phenylsulfonyl)-1H-Indazole
There total 12 articles about 4-[5-(bromomethyl)-2-oxazolyl]-6-chloro-1-(phenylsulfonyl)-1H-Indazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
{2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazol-5-yl}methanol;
With
dibromotriphenylphosphorane;
In
dichloromethane;
at 20 ℃;
for 1h;
Large scale;
With
sodium hydrogencarbonate;
In
methanol; dichloromethane;
Large scale;
DOI:10.1021/acs.oprd.8b00006
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: diammonium sulfide / water; ethanol
2.1: sodium nitrite
3.1: nickel; hydrazine hydrate
4.1: acetic acid; acetic anhydride
5.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / tetrahydrofuran
6.1: lithium hexamethyldisilazane; zinc(II) chloride / tetrahydrofuran / -10 °C
6.2: 60 °C
7.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 0 °C
8.1: bromine; triphenylphosphine / dichloromethane
With
diammonium sulfide; bromine; tetra(n-butyl)ammonium hydrogensulfate; acetic anhydride; nickel; diisobutylaluminium hydride; hydrazine hydrate; acetic acid; triphenylphosphine; sodium hydroxide; zinc(II) chloride; lithium hexamethyldisilazane; sodium nitrite;
In
tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/acs.oprd.0c00486
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / tetrahydrofuran / 1.05 h / 17 - 23 °C / Inert atmosphere
1.2: 1.17 h / 25 °C
2.1: lithium hexamethyldisilazane; zinc(II) chloride / tetrahydrofuran / 1.25 h / -15 - -5 °C / Inert atmosphere
2.2: 6 h / 57 - 63 °C / Inert atmosphere
3.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 0.5 h / -3 - 3 °C / Inert atmosphere
4.1: dibromotriphenylphosphorane / dichloromethane / 0.33 h / 7 - 13 °C / Inert atmosphere
With
diisobutylaluminium hydride; sodium hydroxide; zinc(II) chloride; lithium hexamethyldisilazane; dibromotriphenylphosphorane;
tetra(n-butyl)ammonium hydrogensulfate;
In
tetrahydrofuran; dichloromethane; toluene;
