4-[5-(bromomethyl)-2-oxazolyl]-6-chloro-1-(phenylsulfonyl)-1H-Indazole

Base Information

Chemical Name:4-[5-(bromomethyl)-2-oxazolyl]-6-chloro-1-(phenylsulfonyl)-1H-Indazole
CAS No.:1254036-84-4
Molecular Formula:C₁₇H₁₁BrClN₃O₃S
Molecular Weight:452.716
Hs Code.:
Mol file:1254036-84-4.mol

Synonyms:4-[5-(bromomethyl)-2-oxazolyl]-6-chloro-1-(phenylsulfonyl)-1H-Indazole

Suppliers and Price of 4-[5-(bromomethyl)-2-oxazolyl]-6-chloro-1-(phenylsulfonyl)-1H-Indazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of 4-[5-(bromomethyl)-2-oxazolyl]-6-chloro-1-(phenylsulfonyl)-1H-Indazole

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of 4-[5-(bromomethyl)-2-oxazolyl]-6-chloro-1-(phenylsulfonyl)-1H-Indazole

There total 12 articles about 4-[5-(bromomethyl)-2-oxazolyl]-6-chloro-1-(phenylsulfonyl)-1H-Indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 1254036-83-3
{2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazol-5-yl}methanol

: 1254036-84-4
4-[5-(bromomethyl)-1,3-oxazol-2-yl]-6-chloro-1-(phenylsulfonyl)-1H-indazole

Guidance literature:: {2-[6-chloro-1-(phenylsulfonyl)-1H-indazol-4-yl]-1,3-oxazol-5-yl}methanol; With dibromotriphenylphosphorane; In dichloromethane; at 20 ℃; for 1h; Large scale;

With sodium hydrogencarbonate; In methanol; dichloromethane; Large scale;
DOI:10.1021/acs.oprd.8b00006

Reference yield:

: 35572-79-3
5-chloro-2-methyl-1,3-dinitro-benzene

: 1254036-84-4
4-[5-(bromomethyl)-1,3-oxazol-2-yl]-6-chloro-1-(phenylsulfonyl)-1H-indazole

Guidance literature:: Multi-step reaction with 8 steps

1.1: diammonium sulfide / water; ethanol

2.1: sodium nitrite

3.1: nickel; hydrazine hydrate

4.1: acetic acid; acetic anhydride

5.1: tetra(n-butyl)ammonium hydrogensulfate; sodium hydroxide / tetrahydrofuran

6.1: lithium hexamethyldisilazane; zinc(II) chloride / tetrahydrofuran / -10 °C

6.2: 60 °C

7.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 0 °C

8.1: bromine; triphenylphosphine / dichloromethane

With diammonium sulfide; bromine; tetra(n-butyl)ammonium hydrogensulfate; acetic anhydride; nickel; diisobutylaluminium hydride; hydrazine hydrate; acetic acid; triphenylphosphine; sodium hydroxide; zinc(II) chloride; lithium hexamethyldisilazane; sodium nitrite; In tetrahydrofuran; ethanol; dichloromethane; water; toluene;
DOI:10.1021/acs.oprd.0c00486

Reference yield:

: 98-09-9
benzenesulfonyl chloride

: 1254036-84-4
4-[5-(bromomethyl)-1,3-oxazol-2-yl]-6-chloro-1-(phenylsulfonyl)-1H-indazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / tetra(n-butyl)ammonium hydrogensulfate / tetrahydrofuran / 1.05 h / 17 - 23 °C / Inert atmosphere

1.2: 1.17 h / 25 °C

2.1: lithium hexamethyldisilazane; zinc(II) chloride / tetrahydrofuran / 1.25 h / -15 - -5 °C / Inert atmosphere

2.2: 6 h / 57 - 63 °C / Inert atmosphere

3.1: diisobutylaluminium hydride / toluene; tetrahydrofuran / 0.5 h / -3 - 3 °C / Inert atmosphere

4.1: dibromotriphenylphosphorane / dichloromethane / 0.33 h / 7 - 13 °C / Inert atmosphere

With diisobutylaluminium hydride; sodium hydroxide; zinc(II) chloride; lithium hexamethyldisilazane; dibromotriphenylphosphorane; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; dichloromethane; toluene;