N-benzyloxy-3-chlorobenzamide

Base Information

• Chemical Name: N-benzyloxy-3-chlorobenzamide
• CAS No.: 7335-36-6
• Molecular Formula: C₁₄H₁₂ClNO₂
• Molecular Weight: 261.708
• Mol file: 7335-36-6.mol

Synonyms:N-benzyloxy-3-chlorobenzamide

Chemical Property of N-benzyloxy-3-chlorobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of N-benzyloxy-3-chlorobenzamide

There total 3 articles about N-benzyloxy-3-chlorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

N-benzyloxyamine (622-33-3) + 3-chlorobenzoate (535-80-8) → N-benzyloxy-3-chlorobenzamide (7335-36-6)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; 1H-benzo[d][1,2,3]triazol-1-yl 4-methanebenzenesulfonate; In acetonitrile; at 0 - 20 ℃; Green chemistry;

DOI:10.1039/c3ra44294b

Reference yield:

O-benzylhydoxylamine hydrochloride (2687-43-6) + m-Chlorobenzoyl chloride (618-46-2) → N-benzyloxy-3-chlorobenzamide (7335-36-6)

Guidance literature:

With pyridine;

Reference yield:

3-chlorobenzoate (535-80-8) → N-benzyloxy-3-chlorobenzamide (7335-36-6)

Guidance literature:

Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 0 - 20 °C

2: sodium carbonate / dichloromethane; water / 2 h / 0 °C / Cooling with ice

With oxalyl dichloride; sodium carbonate; N,N-dimethyl-formamide; In dichloromethane; water;

DOI:10.1021/acs.joc.6b00111

upstream raw materials:

O-benzylhydoxylamine hydrochloride

m-Chlorobenzoyl chloride

N-benzyloxyamine

3-chlorobenzoate

Refernces

• 1、 Palakurthy, Nani Babu,Dev, Dharm,Paikaray, Sonali,Chaudhury, Susmitnarayan,Mandal, Bhubaneswar. "Synthesis of O-benzyl hydroxamates employing the sulfonate esters of N-hydroxybenzotriazole". . p. 7952 - 7958. Retrieved 2014/02/14.