(S)-4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-butyric acid benzyl ester

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Chemical Name:(S)-4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-butyric acid benzyl ester
CAS No.:102651-02-5
Molecular Formula:C₃₄H₃₁N₉O₇
Molecular Weight:677.676
Hs Code.:

Synonyms:(S)-4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-butyric acid benzyl ester

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Chemical Property of (S)-4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-butyric acid benzyl ester

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Technology Process of (S)-4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-butyric acid benzyl ester

There total 1 articles about (S)-4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-butyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 89043-75-4
4-amino-4-deoxy-N¹⁰-formylpteroic acid

: 102651-21-8
L-glutamic acid α-benzyl-γ-(3,4-methylenedioxyphenylamide) p-toluenesulfonate salt

: 102651-02-5
(S)-4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-butyric acid benzyl ester

Guidance literature:: With triethylamine; isobutyl chloroformate; In water; N,N-dimethyl-formamide; for 75h; Ambient temperature;
DOI:10.1021/jm00159a023

Reference yield:

: 102651-02-5
(S)-4-(Benzo[1,3]dioxol-5-ylcarbamoyl)-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-butyric acid benzyl ester

: 102650-95-3
(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoylamino}-4-(3,4-dihydroxy-phenylcarbamoyl)-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / 0.25 N NaOH, 10percent AcOH / methanol / 72 h / 25 °C

2: 79 percent / 0.5 M boron tris(trifluoroacetate) / trifluoroacetic acid / 1.) 0 deg C, 15 min, 2.) RT, 3 h

With sodium hydroxide; tris(trifluoro acetyloxy)borane; acetic acid; In methanol; trifluoroacetic acid;
DOI:10.1021/jm00159a023